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Literature DB >> 4689836

Amodiaquine-induced agranulocytosis: toxic effect of amodiaquine in bone marrow cultures in vitro.

Abstract

A case of agranulocytosis is reported in which amodiaquine, to which the patient had been exposed, was found to be toxic to the patient's bone marrow cells when these were cultured in an agar colony system in vitro. This technique should be investigated in other patients with agranulocytosis as a possible means of detecting toxic agents.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1973 PMID： 4689836 PMCID： PMC1588506 DOI： 10.1136/bmj.1.5851.458

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

7 in total

1. Fatal agranulocytosis during treatment with a amodiaquine.

Authors: L GLICK
Journal: Br Med J Date: 1957-04-20

2. Absolute neutrophil leucopenia after uncontrolled use of amodiaquine.

Authors: A F KENNEDY
Journal: Br Med J Date: 1955-08-20

3. Nearly fatal reaction to amodiaquine.

Authors: H O PERRY; L G BARTHOLOMEW; D G HANLON
Journal: JAMA Date: 1962-02-24 Impact factor: 56.272

4. Heterologous aortic valve transplantation.

Authors: J P Binet; C G Duran; A Carpenter; J Langlois
Journal: Lancet Date: 1965-12-18 Impact factor: 79.321

5. Hydroxychloroquine-induced agranulocytosis.

Authors: D Chernof; K S Taylor
Journal: Arch Dermatol Date: 1968-02

6. Agranulocytosis coincident with amodiaquine therapy.

Authors: K Booth; K Larkin; I Maddocks
Journal: Br Med J Date: 1967-07-01

7. Evaluation of amodiaquin (camoquin) in the treatment of relapsing vivax malaria.

Authors: J LOVE; R FOULK; R G W WILLIAMS; R B MITCHELL
Journal: Am J Med Sci Date: 1953-01 Impact factor: 2.378

7 in total

18 in total

1. Effect of monodesethyl amodiaquine on human polymorphonuclear neutrophil functions in vitro.

Authors: M T Labro; J el Benna
Journal: Antimicrob Agents Chemother Date: 1991-05 Impact factor: 5.191

Review 2. [Drug-induced agranulocytoses].

Authors: R Gross; K P Hellriegel
Journal: Blut Date: 1976-06

Amodiaquine-induced agranulocytosis: toxic effect of amodiaquine in bone marrow cultures in vitro.

1. Fatal agranulocytosis during treatment with a amodiaquine.

2. Absolute neutrophil leucopenia after uncontrolled use of amodiaquine.

3. Nearly fatal reaction to amodiaquine.

4. Heterologous aortic valve transplantation.

5. Hydroxychloroquine-induced agranulocytosis.

6. Agranulocytosis coincident with amodiaquine therapy.

7. Evaluation of amodiaquin (camoquin) in the treatment of relapsing vivax malaria.

1. Effect of monodesethyl amodiaquine on human polymorphonuclear neutrophil functions in vitro.

Review 2. [Drug-induced agranulocytoses].

Review 3. Recent updates in the discovery and development of novel antimalarial drug candidates.

4. Amodiaquine induced agranulocytosis: inhibition of colony growth in bone marrow by antimalarial agents.

5. Relevance of in vitro studies of drug-induced agranulocytosis. Report of 14 cases.

Review 6. In vitro evidence of drug action in aplastic anemia.

7. Effects of amodiaquine, chloroquine, and mefloquine on human polymorphonuclear neutrophil function in vitro.

8. Mechanism of clozapine-induced agranulocytosis : current status of research and implications for drug development.

9. The disposition of amodiaquine in man after oral administration.

10. Drug-induced aplastic anaemia and agranulocytosis. Incidence and mechanisms.