Literature DB >> 843794

Preventing venous thromboembolism in elderly patients with hip fractures: studies of low-dose heparin, dipyridamole, aspirin, and flurbiprofen.

G K Morris, J R Mitchell.   

Abstract

Low-dose heparin, dipyridamole (alone and in combination with aspirin), and flurbiprofen were evaluated as potential prophylactic agents against deep venous thrombosis in elderly patients with hip fractures. None of the agents that modify platelet behaviour could reduct the frequency of isotopically diagnosed venous thrombosis. Low-dose heparin reduced the overall frequency of venous thrombosis and its extent as judged by the frequency of bilaterally abnormal scans, but this reduction did not achieve statistical significance.

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Year:  1977        PMID: 843794      PMCID: PMC1605162          DOI: 10.1136/bmj.1.6060.535

Source DB:  PubMed          Journal:  Br Med J        ISSN: 0007-1447


  16 in total

1.  Prevention of venous thrombosis and pulmonary embolism in injured patients. A trial of anticoagulant prophylaxis with phenindione in middle-aged and elderly patients with fractured necks of femur.

Authors:  S SEVITT; N G GALLAGHER
Journal:  Lancet       Date:  1959-12-05       Impact factor: 79.321

2.  Small subcutaneous doses of heparin in prevention of venous thrombosis.

Authors:  A S Gallus; J Hirsh; R J Tutle; R Trebilcock; S E O'Brien; J J Carroll; J H Minden; S M Hudecki
Journal:  N Engl J Med       Date:  1973-03-15       Impact factor: 91.245

Review 3.  Theory and practice of minidose heparin in surgical patients. A status report.

Authors:  S Wessler; E T Yin
Journal:  Circulation       Date:  1973-04       Impact factor: 29.690

4.  Effect of dipyridamole on the incidence of clinically detectable deep-vein thrombosis.

Authors:  N L Browse; J H Hall
Journal:  Lancet       Date:  1969-10-04       Impact factor: 79.321

5.  Inhibition of adenosine diphosphate-induced secondary aggregation and other platelet functions by acetylsalicylic acid ingestion.

Authors:  M B Zucker; J Peterson
Journal:  Proc Soc Exp Biol Med       Date:  1968-02

6.  Studies of platelet and fibrinogen kinetics in patients with prosthetic heart valves.

Authors:  L A Harker; S J Slichter
Journal:  N Engl J Med       Date:  1970-12-10       Impact factor: 91.245

7.  Reduction in venous thromboembolism by agents affecting platelet function.

Authors:  E W Salzman; W H Harris; R W DeSanctis
Journal:  N Engl J Med       Date:  1971-06-10       Impact factor: 91.245

8.  Effect of dipyridamole on human platelet behaviour.

Authors:  P R Emmons; M J Harrison; A J Honour; J R Mitchell
Journal:  Lancet       Date:  1965-09-25       Impact factor: 79.321

9.  Effect of a pyrimidopyrimidine derivative on thrombus formation in the rabbit.

Authors:  P R Emmons; M J Harrison; A J Honour; J R Mitchell
Journal:  Nature       Date:  1965-10-16       Impact factor: 49.962

10.  Prevention of postoperative deep vein thrombosis with dipyridamole and aspirin.

Authors:  J T Renney; E F O'Sullivan; P F Burke
Journal:  Br Med J       Date:  1976-04-24
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  11 in total

1.  Prevention of VTE in orthopedic surgery patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.

Authors:  Yngve Falck-Ytter; Charles W Francis; Norman A Johanson; Catherine Curley; Ola E Dahl; Sam Schulman; Thomas L Ortel; Stephen G Pauker; Clifford W Colwell
Journal:  Chest       Date:  2012-02       Impact factor: 9.410

2.  Can we really prevent postoperative pulmonary emboli?

Authors:  J R Mitchell
Journal:  Br Med J       Date:  1979-06-09

Review 3.  Physiological changes due to age. Implications for the prevention and treatment of thrombosis in older patients.

Authors:  M T Nurmohamed; H R Büller; J W ten Cate
Journal:  Drugs Aging       Date:  1994-07       Impact factor: 3.923

4.  Deep vein thrombosis and anaesthetic technique in emergency hip surgery.

Authors:  F M Davis; M Quince; V G Laurenson
Journal:  Br Med J       Date:  1980-12-06

Review 5.  Prophylaxis of venous thromboembolism.

Authors:  V V Kakkar; M D Stringer
Journal:  World J Surg       Date:  1990 Sep-Oct       Impact factor: 3.352

6.  Collaborative overview of randomised trials of antiplatelet therapy--III: Reduction in venous thrombosis and pulmonary embolism by antiplatelet prophylaxis among surgical and medical patients. Antiplatelet Trialists' Collaboration.

Authors: 
Journal:  BMJ       Date:  1994-01-22

Review 7.  [Thrombosis prevention with heparin/dihydroergotamine versus heparin/Sintrom in Ender nailing of pertrochanteric fractures].

Authors:  G Schlag; T Gaudernak; H Pelinka; H Redl; H Kuderna; J Poigenfürst
Journal:  Unfallchirurgie       Date:  1988-02

Review 8.  Antiplatelet drugs: clinical pharmacology and therapeutic use.

Authors:  A S Gallus
Journal:  Drugs       Date:  1979-12       Impact factor: 9.546

Review 9.  Flurbiprofen: a review of its pharmacological properties and therapeutic use in rheumatic diseases.

Authors:  R N Brogden; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1979-12       Impact factor: 9.546

10.  [Clinical and in-vitro studies of the therapeutical range of acetylsalicylic-acid to prevent deep vein thrombosis (author's transl)].

Authors:  T H Schöndorf; D Hey; H G Lasch
Journal:  Klin Wochenschr       Date:  1978-11-15
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