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Literature DB >> 773495

Prevention of postoperative deep vein thrombosis with dipyridamole and aspirin.

Abstract

One hundred and sixty patients have been studied in a controlled trial of two drugs which have been in combination to prevent postoperative-deep-vein thrombosis. Both the drugs, dipyridamole (Persantin) and aspirin, were given by mouth from the evening before operation and for seven days after operation. The radioactive fibrinogen test was used to diagnose thrombosis. Of the 85 patients in the control group 24 developed thrombosis (28%). Twelve out of 85 patients (14%) in the test group were found to have thrombosis. Similar significant differences in incidence were found in the various subgroups.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Dipyridamole
Aspirin

Year: 1976 PMID： 773495 PMCID： PMC1639649 DOI： 10.1136/bmj.1.6016.992

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

22 in total

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Authors: S SEVITT; N GALLAGHER
Journal: Br J Surg Date: 1961-03 Impact factor: 6.939

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Authors: S Bygdeman; R Eliasson; S Johnson
Journal: Lancet Date: 1966-06-11 Impact factor: 79.321

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Authors:
Journal: Lancet Date: 1972-09-02 Impact factor: 79.321

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Journal: BMJ Date: 1994-01-22

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Authors: I A Reilly; G A FitzGerald
Journal: Drugs Date: 1988-02 Impact factor: 9.546

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Authors: A S Gallus
Journal: Drugs Date: 1979-12 Impact factor: 9.546

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Authors: G P Clagett; J S Reisch
Journal: Ann Surg Date: 1988-08 Impact factor: 12.969

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Authors: T H Schöndorf; D Hey; H G Lasch
Journal: Klin Wochenschr Date: 1978-11-15

8. Preventing venous thromboembolism in elderly patients with hip fractures: studies of low-dose heparin, dipyridamole, aspirin, and flurbiprofen.

Authors: G K Morris; J R Mitchell
Journal: Br Med J Date: 1977-02-26

9. Value of anticoagulants in the treatment of pulmonary embolism: a discussion paper.

Authors: P Egermayer
Journal: J R Soc Med Date: 1981-09 Impact factor: 18.000

9 in total

Prevention of postoperative deep vein thrombosis with dipyridamole and aspirin.

1. Venous thrombosis and pulmonary embolism. A clinico-pathological study in injured and burned patients.

2. Relationship between postoperative changes in adenosine-diphosphate induced platelet adhesiveness and venous thrombosis.

3. Effect of aspirin on postoperative venous thrombosis. Report of the Steering Committee of a trial sponsored by the Medical Research Council.

4. Low doses of heparin in prevention of deep-vein thrombosis.

Review 5. Factors influencing platelet function: adhesion, release, and aggregation.

6. Platelet adhesiveness in postoperative deep-vein thrombosis.

7. Effect of dipyridamole on the incidence of clinically detectable deep-vein thrombosis.

8. Natural history of postoperative deep-vein thrombosis.

9. Deep vein thrombosis of the leg. Is there a "high risk" group?

10. Effect of dipyridamole on human platelet behaviour.

1. Prevention of postoperative deep venous thrombosis.

Review 2. Prophylaxis of venous thromboembolism.