Literature DB >> 8437229

Vaccinia virus-specific CD8+ cytotoxic T lymphocytes in humans.

W E Demkowicz1, F A Ennis.   

Abstract

Stimulation of human vaccinia virus immune peripheral blood mononuclear cells in vitro from vaccinia virus-immune donors with live vaccinia virus-infected autologous cells generated vaccinia virus-specific cytotoxic T lymphocytes (CTL) capable of lysing vaccinia virus-infected cells. We generated vaccinia virus-specific CD8+ clones and CD4+ CTL lines by limiting dilution from two donors by using peripheral blood mononuclear cells obtained 2 months or 4 years postrevaccination with vaccinia virus. These results demonstrate that vaccinia virus-specific CTL are generated as a result of immunization of humans with vaccinia virus and that both CD8(+)- and CD4(+)-specific T cells are maintained as memory cells.

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Year:  1993        PMID： 8437229      PMCID： PMC237524     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  26 in total

1.  PROGRESSIVE VACCINIA WITH NORMAL ANTIBODIES. A CASE POSSIBLY DUE TO DEFICIENT CELLULAR IMMUNITY.

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Journal:  Ann Intern Med       Date:  1964-02       Impact factor: 25.391

2.  Proliferative and cytotoxic T cells to AIDS virus glycoproteins in chimpanzees immunized with a recombinant vaccinia virus expressing AIDS virus envelope glycoproteins.

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Journal:  J Immunol       Date:  1987-08-15       Impact factor: 5.422

3.  Immune response in humans after vaccination with vaccinia virus: generation of a virus-specific cytotoxic activity by human peripheral lymphocytes.

Authors:  L H Perrin; R M Zinkernagel; M B Oldstone
Journal:  J Exp Med       Date:  1977-10-01       Impact factor: 14.307

4.  Immune response against vaccinia virus in rhesus monkeys: no evidence for primary MHC-restricted cytolytic T cells.

Authors:  L Stitz; R Zinkernagel; C M Balch; R L Bolhuis; H Balner
Journal:  Exp Cell Biol       Date:  1984

5.  Cell-mediated immune response to lymphocytic choriomeningitis and vaccinia virus in rats.

Authors:  R M Zinkernagel; A Althage; F C Jensen
Journal:  J Immunol       Date:  1977-10       Impact factor: 5.422

6.  Characteristics of poxvirus-induced meningitis: virus-specific and non-specific cytotoxic effectors in the inflammatory exudate.

Authors:  P C Doherty; R Korngold
Journal:  Scand J Immunol       Date:  1983-07       Impact factor: 3.487

7.  Vaccinia virus proteins on the plasma membranes of infected cells. II. Expression of viral antigens and killing of infected cells by vaccinia virus-specific cytotoxic T cells.

Authors:  V R Mallon; E A Domber; J A Holowczak
Journal:  Virology       Date:  1985-08       Impact factor: 3.616

8.  Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus in vivo.

Authors:  J A Byrne; M B Oldstone
Journal:  J Virol       Date:  1984-09       Impact factor: 5.103

9.  Kinetics of cytotoxic lymphocytes in efferent lymph from single lymph nodes following immunization with vaccinia virus.

Authors:  T B Issekutz
Journal:  Clin Exp Immunol       Date:  1984-06       Impact factor: 4.330

10.  Cytotoxic T-cell responses in mice infected with influenza and vaccinia viruses vary in magnitude with H-2 genotype.

Authors:  P C Doherty; W E Biddison; J R Bennink; B B Knowles
Journal:  J Exp Med       Date:  1978-08-01       Impact factor: 14.307
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  15 in total

1.  Diversity in the acute CD8 T cell response to vaccinia virus in humans.

Authors:  Lichen Jing; Tiana M Chong; Christopher L McClurkan; Jay Huang; Brian T Story; David M Koelle
Journal:  J Immunol       Date:  2005-12-01       Impact factor: 5.422

2.  On the role of antigen in maintaining cytotoxic T-cell memory.

Authors:  T M Kündig; M F Bachmann; S Oehen; U W Hoffmann; J J Simard; C P Kalberer; H Pircher; P S Ohashi; H Hengartner; R M Zinkernagel
Journal:  Proc Natl Acad Sci U S A       Date:  1996-09-03       Impact factor: 11.205

3.  Recombinant vaccinia virus-induced T-cell immunity: quantitation of the response to the virus vector and the foreign epitope.

Authors:  Laurie E Harrington; Robbert van der Most Rv; J Lindsay Whitton; Rafi Ahmed
Journal:  J Virol       Date:  2002-04       Impact factor: 5.103

4.  Cross-reactivities in memory cytotoxic T lymphocyte recognition of heterologous viruses.

Authors:  L K Selin; S R Nahill; R M Welsh
Journal:  J Exp Med       Date:  1994-06-01       Impact factor: 14.307

5.  Reduction of otherwise remarkably stable virus-specific cytotoxic T lymphocyte memory by heterologous viral infections.

Authors:  L K Selin; K Vergilis; R M Welsh; S R Nahill
Journal:  J Exp Med       Date:  1996-06-01       Impact factor: 14.307

6.  Human cytotoxic T-cell memory: long-lived responses to vaccinia virus.

Authors:  W E Demkowicz; R A Littaua; J Wang; F A Ennis
Journal:  J Virol       Date:  1996-04       Impact factor: 5.103

7.  Orthopoxvirus genes that mediate disease virulence and host tropism.

Authors:  Sergei N Shchelkunov
Journal:  Adv Virol       Date:  2012-07-30

8.  Origin and differentiation of human memory CD8 T cells after vaccination.

Authors:  Rama S Akondy; Mark Fitch; Srilatha Edupuganti; Shu Yang; Haydn T Kissick; Kelvin W Li; Ben A Youngblood; Hossam A Abdelsamed; Donald J McGuire; Kristen W Cohen; Gabriela Alexe; Shashi Nagar; Megan M McCausland; Satish Gupta; Pramila Tata; W Nicholas Haining; M Juliana McElrath; David Zhang; Bin Hu; William J Greenleaf; Jorg J Goronzy; Mark J Mulligan; Marc Hellerstein; Rafi Ahmed
Journal:  Nature       Date:  2017-12-13       Impact factor: 69.504

9.  Vaccinia scars associated with improved survival among adults in rural Guinea-Bissau.

Authors:  Mette Lundsby Jensen; Sangeeta Dave; Maarten Schim van der Loeff; Carlos da Costa; Tim Vincent; Aleksandra Leligdowicz; Christine Stabell Benn; Adam Roth; Henrik Ravn; Ida Maria Lisse; Hilton Whittle; Peter Aaby
Journal:  PLoS One       Date:  2006-12-20       Impact factor: 3.240

10.  Flow cytometry and T-cell response monitoring after smallpox vaccination.

Authors:  Fabrizio Poccia; Cristiana Gioia; Carla Montesano; Federico Martini; Douglas Horejsh; Concetta Castilletti; Leopoldo paolo Pucillo; Maria Rosaria Capobianchi; Giuseppe Ippolito
Journal:  Emerg Infect Dis       Date:  2003-11       Impact factor: 6.883
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