Literature DB >> 8437212

Proliferative response of Tax1-transduced primary human T cells to anti-CD3 antibody stimulation by an interleukin-2-independent pathway.

T Akagi1, K Shimotohno.   

Abstract

The growth properties of human T-cell leukemia virus Tax1-transduced primary human T cells derived from peripheral blood lymphocytes were compared with those of the same subset of T cells transduced with a control vector. Tax1-transduced T cells exhibited slightly elevated responsiveness to externally added interleukin-2 (IL-2) and a markedly higher proliferative response to stimulation with anti-CD3 antibody. The proliferation after anti-CD3 antibody stimulation was mainly via an IL-2-independent pathway. Therefore, some other mechanism than the previously proposed IL-2 autocrine model seems to be involved in the process of deregulation of T-cell proliferation by Tax1. Moreover, Tax1-transduced T cells have continued to proliferate in medium containing IL-2 long after control T cells ceased to grow, and so they are considered to be immortalized.

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Year:  1993        PMID： 8437212      PMCID： PMC237486     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  55 in total

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Authors:  T J Laing; A Weiss
Journal:  J Immunol       Date:  1988-02-15       Impact factor: 5.422

2.  Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells.

Authors:  I Miyoshi; I Kubonishi; S Yoshimoto; T Akagi; Y Ohtsuki; Y Shiraishi; K Nagata; Y Hinuma
Journal:  Nature       Date:  1981-12-24       Impact factor: 49.962

3.  Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease.

Authors:  M Yoshida; I Miyoshi; Y Hinuma
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

4.  Transformation of human leukocytes by cocultivation with an adult T cell leukemia virus producer cell line.

Authors:  N Yamamoto; M Okada; Y Koyanagi; M Kannagi; Y Hinuma
Journal:  Science       Date:  1982-08-20       Impact factor: 47.728

5.  Transformation of human umbilical cord blood T cells by human T-cell leukemia/lymphoma virus.

Authors:  M Popovic; G Lange-Wantzin; P S Sarin; D Mann; R C Gallo
Journal:  Proc Natl Acad Sci U S A       Date:  1983-09       Impact factor: 11.205

6.  Establishment and characterization of 10 cell lines derived from patients with adult T-cell leukemia.

Authors:  H Hoshino; H Esumi; M Miwa; M Shimoyama; K Minato; K Tobinai; M Hirose; S Watanabe; N Inada; K Kinoshita; S Kamihira; M Ichimaru; T Sugimura
Journal:  Proc Natl Acad Sci U S A       Date:  1983-10       Impact factor: 11.205

7.  Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera.

Authors:  Y Hinuma; K Nagata; M Hanaoka; M Nakai; T Matsumoto; K I Kinoshita; S Shirakawa; I Miyoshi
Journal:  Proc Natl Acad Sci U S A       Date:  1981-10       Impact factor: 11.205

8.  Structure and expression of a cloned cDNA for human interleukin-2.

Authors:  T Taniguchi; H Matsui; T Fujita; C Takaoka; N Kashima; R Yoshimoto; J Hamuro
Journal:  Nature       Date:  1983 Mar 24-30       Impact factor: 49.962

9.  Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA.

Authors:  M Seiki; S Hattori; Y Hirayama; M Yoshida
Journal:  Proc Natl Acad Sci U S A       Date:  1983-06       Impact factor: 11.205

10.  Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones.

Authors:  S C Meuer; J C Hodgdon; R E Hussey; J P Protentis; S F Schlossman; E L Reinherz
Journal:  J Exp Med       Date:  1983-09-01       Impact factor: 14.307
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  43 in total

1.  Mouse models of human T lymphotropic virus type-1-associated adult T-cell leukemia/lymphoma.

Authors:  B Zimmerman; S Niewiesk; M D Lairmore
Journal:  Vet Pathol       Date:  2010-05-04       Impact factor: 2.221

Review 2.  Molecular mechanisms of HTLV-1 infection and pathogenesis.

Authors:  Junichiro Yasunaga; Masao Matsuoka
Journal:  Int J Hematol       Date:  2011-09-28       Impact factor: 2.490

3.  Constitutive expression of the HTLV-I pX and env regions in Jurkat T-cells induces differential activation of SRE, CRE and NF kappa B pathways.

Authors:  A C Black; J Luo; S Chun; S Tabibzadeh
Journal:  Virus Genes       Date:  1997       Impact factor: 2.332

4.  Human T cell leukemia virus type 2 (HTLV-2) Tax2 has a dominant activity over HTLV-1 Tax1 to immortalize human CD4+ T cells.

Authors:  Michitaka Imai; Masaya Higuchi; Hiroki Kawamura; Manami Yoshita; Masahiko Takahashi; Masayasu Oie; Hideaki Matsuki; Yuetsu Tanaka; Yutaka Aoyagi; Masahiro Fujii
Journal:  Virus Genes       Date:  2012-09-29       Impact factor: 2.332

5.  Cooperation of NF-kappaB2/p100 activation and the PDZ domain binding motif signal in human T-cell leukemia virus type 1 (HTLV-1) Tax1 but not HTLV-2 Tax2 is crucial for interleukin-2-independent growth transformation of a T-cell line.

Authors:  Masaya Higuchi; Chikako Tsubata; Rie Kondo; Sakiko Yoshida; Masahiko Takahashi; Masayasu Oie; Yuetsu Tanaka; Renaud Mahieux; Masao Matsuoka; Masahiro Fujii
Journal:  J Virol       Date:  2007-08-22       Impact factor: 5.103

6.  The viral oncoprotein tax sequesters DNA damage response factors by tethering MDC1 to chromatin.

Authors:  S Mehdi Belgnaoui; Kimberly A Fryrear; Julius O Nyalwidhe; Xin Guo; O John Semmes
Journal:  J Biol Chem       Date:  2010-08-20       Impact factor: 5.157

7.  Human T-cell leukemia virus type 1 tax protein abrogates interleukin-2 dependence in a mouse T-cell line.

Authors:  Y Iwanaga; T Tsukahara; T Ohashi; Y Tanaka; M Arai; M Nakamura; K Ohtani; Y Koya; M Kannagi; N Yamamoto; M Fujii
Journal:  J Virol       Date:  1999-02       Impact factor: 5.103

8.  Human T-cell leukemia virus type 1 (HTLV-1) Tax1 oncoprotein but not HTLV-2 Tax2 induces the expression of OX40 ligand by interacting with p52/p100 and RelB.

Authors:  Yosuke Motai; Masahiko Takahashi; Takayuki Takachi; Masaya Higuchi; Toshifumi Hara; Mariko Mizuguchi; Yutaka Aoyagi; Shuji Terai; Yuetsu Tanaka; Masahiro Fujii
Journal:  Virus Genes       Date:  2016-01-06       Impact factor: 2.332

9.  Identification of a novel motif responsible for the distinctive transforming activity of human T-cell leukemia virus (HTLV) type 1 Tax1 protein from HTLV-2 Tax2.

Authors:  Toshiyuki Shoji; Masaya Higuchi; Rie Kondo; Masahiko Takahashi; Masayasu Oie; Yuetsu Tanaka; Yutaka Aoyagi; Masahiro Fujii
Journal:  Retrovirology       Date:  2009-09-17       Impact factor: 4.602

Review 10.  Distinct functions of HTLV-1 Tax1 from HTLV-2 Tax2 contribute key roles to viral pathogenesis.

Authors:  Masaya Higuchi; Masahiro Fujii
Journal:  Retrovirology       Date:  2009-12-17       Impact factor: 4.602
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