Literature DB >> 843324

The release of calcium from cardiac mitochondria: the importance of the calcium-protein ratio.

G G Göring, W G Nayler, P G Spieckermann.   

Abstract

Using a DW 2 dual wavelength spectrophotometer (AMINCO) and murexide as a Ca2+ sensitive indicator it is shown that guinea-pig heart mitochondria can release accumulated Ca2+ without the influence of non-physiological material. The main factor which decides if accumulated Ca2+ is spontaneously released is the Ca2+/mitochondrial-protein ratio. Under appropriate assay conditions a critical intramitochondrial Ca2+ concentration is reached. Increasing this concentration leads to Ca2+-release.

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Year:  1977        PMID： 843324     DOI： 10.1007/BF01906303

Source DB:  PubMed          Journal:  Basic Res Cardiol        ISSN： 0300-8428            Impact factor:   17.165


  12 in total

Review 1.  Mitochondria, Ca2+ transport and the regulation of heart contraction and metabolism.

Authors:  E Carafoli
Journal:  J Mol Cell Cardiol       Date:  1975-02       Impact factor: 5.000

2.  THE ENERGY-LINKED REACTION OF CALCIUM WITH MITOCHONDRIA.

Authors:  B CHANCE
Journal:  J Biol Chem       Date:  1965-06       Impact factor: 5.157

3.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

4.  A microspectrophotometric method for the determination of cytochrome oxidase.

Authors:  S J COOPERSTEIN; A LAZAROW
Journal:  J Biol Chem       Date:  1951-04       Impact factor: 5.157

5.  A microspectrophotometric method for the determination of succinic dehydrogenase.

Authors:  S J COOPERSTEIN; A LAZAROW; N J KURFESS
Journal:  J Biol Chem       Date:  1950-09       Impact factor: 5.157

6.  Mitochondria and sarcoplasmic reticulum function in cardiac hypertrophy and failure.

Authors:  L A Sordahl; W B McCollum; W G Wood; A Schwartz
Journal:  Am J Physiol       Date:  1973-03

7.  Specific inhibition of mitochondrial Ca++ transport by ruthenium red.

Authors:  C L Moore
Journal:  Biochem Biophys Res Commun       Date:  1971-01-22       Impact factor: 3.575

8.  The release of calcium from heart mitochondria by sodium.

Authors:  E Carafoli; R Tiozzo; G Lugli; F Crovetti; C Kratzing
Journal:  J Mol Cell Cardiol       Date:  1974-08       Impact factor: 5.000

9.  Possible role of mitochondria in regulation of cardiac contractility.

Authors:  N Haugaard; E S Haugaard; N H Lee; R S Forn
Journal:  Fed Proc       Date:  1969 Sep-Oct

10.  A protective effect of verapamil on hypoxic heart muscle.

Authors:  W G Nayler; A Grau; A Slade
Journal:  Cardiovasc Res       Date:  1976-11       Impact factor: 10.787
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  2 in total

1.  Functional alterations of cardiac subcellular structures during energy deficiency in relation to the metabolic state of the heart muscle cell.

Authors:  P G Spieckermann; M M Gebhard; G G Göring; H Kahles; V A Mezger; C J Preusse; M Stellwaag
Journal:  Basic Res Cardiol       Date:  1980 Jan-Feb       Impact factor: 17.165

2.  Ca2+-uptake and -release phenomena from cardiac mitochondria under normal and ischemic conditions.

Authors:  G G Göring; P G Spieckermann
Journal:  Basic Res Cardiol       Date:  1978 Jan-Feb       Impact factor: 17.165
  2 in total

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