Literature DB >> 656015

Ca2+-uptake and -release phenomena from cardiac mitochondria under normal and ischemic conditions.

G G Göring, P G Spieckermann.   

Abstract

Guinea-pig and dog heart mitochondria were isolated in a KEA-medium. Ca2+-transport across mitochondrial membranes was measured continuously with an Aminco Dual-Wavelength-Spectrophotometer and murexide as a Ca2+-sensitive indicator. Ischemia was produced by cardioplegia at 15 degrees C according to Bretschneider. Guinea-pig heart mitochondria as well as mitochondria from dog heart show a spontaneous Ca2+-release without nonphysiological influence. Addition of 3.5 M Na+ can induce a very quick release of Ca2+ taken up by heart mitochondria. This release is different from that occurring spontaneously. Progressive ischemia results in a marked depression of Ca2+-uptake and spontaneous Ca2+-release.

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Year:  1978        PMID： 656015     DOI： 10.1007/BF01914660

Source DB:  PubMed          Journal:  Basic Res Cardiol        ISSN： 0300-8428            Impact factor:   17.165


  9 in total

1.  Effects of magnesium, Ruthenium red and the antibiotic ionophore A-23187 on initial rates of calcium uptake and release by heart mitochondria.

Authors:  L A Sordahl
Journal:  Arch Biochem Biophys       Date:  1975-03       Impact factor: 4.013

2.  On the problem of the release of mitochondrial calcium by cyclic AMP.

Authors:  A Scarpa; K Malmstrom; M Chiesi; E Carafoli
Journal:  J Membr Biol       Date:  1976-10-20       Impact factor: 1.843

Review 3.  Events at the cardiac sarcolemma: localization and movement of contractile-dependent calcium.

Authors:  G A Langer
Journal:  Fed Proc       Date:  1976-05-01

4.  Evidence for more than one Ca2+ transport mechanism in mitochondria.

Authors:  J S Puskin; T E Gunter; K K Gunter; P R Russell
Journal:  Biochemistry       Date:  1976-08-24       Impact factor: 3.162

5.  Cyclic AMP stimulation of calcium efflux from kidney, liver and heart mitochondria.

Authors:  A B Borle
Journal:  J Membr Biol       Date:  1974       Impact factor: 1.843

6.  The release of calcium from heart mitochondria by sodium.

Authors:  E Carafoli; R Tiozzo; G Lugli; F Crovetti; C Kratzing
Journal:  J Mol Cell Cardiol       Date:  1974-08       Impact factor: 5.000

7.  The release of calcium from cardiac mitochondria: the importance of the calcium-protein ratio.

Authors:  G G Göring; W G Nayler; P G Spieckermann
Journal:  Basic Res Cardiol       Date:  1977 Jan-Feb       Impact factor: 17.165

Review 8.  Myocardial resistance and tolerance to ischemia: physiological and biochemical basis.

Authors:  H J Bretschneider; G Hübner; D Knoll; B Lohr; H Nordbeck; P G Spieckermann
Journal:  J Cardiovasc Surg (Torino)       Date:  1975 May-Jun       Impact factor: 1.888

9.  Mechanisms for intracellular calcium regulation in heart. I. Stopped-flow measurements of Ca++ uptake by cardiac mitochondria.

Authors:  A Scarpa; P Graziotti
Journal:  J Gen Physiol       Date:  1973-12       Impact factor: 4.086
  9 in total
  2 in total

1.  Functional alterations of cardiac subcellular structures during energy deficiency in relation to the metabolic state of the heart muscle cell.

Authors:  P G Spieckermann; M M Gebhard; G G Göring; H Kahles; V A Mezger; C J Preusse; M Stellwaag
Journal:  Basic Res Cardiol       Date:  1980 Jan-Feb       Impact factor: 17.165

2.  The role of ATP and lactic acid for mitochondrial function during myocardial ischemia.

Authors:  H Kahles; M M Gebhard; V A Mezger; H Nordbeck; C J Preusse; P G Spieckermann
Journal:  Basic Res Cardiol       Date:  1979 Nov-Dec       Impact factor: 17.165
  2 in total

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