Literature DB >> 8431532

Environmental factors and the etiology of melanoma.

J F Ashton1, R S Laura.   

Abstract

In this piece, we have argued that, despite educational programs designed to prevent melanoma, the mortality and incidence rates for the disease have soared steadily. Even on the conventional interpretation of the data, just more than half of the presented cases of melanoma can be explained solely as 'sun-caused.' The conventional interpretation has little to offer by way of explaining the remainder of these cases, some of which, as we discussed earlier, involve melanomas on parts of the body not exposed to the sun. We have argued that the dominant interpretation in which increasing exposures to sunlight account for the increasing incidence of melanomas is a misleading oversimplification. To resolve the melanoma enigma in preventive health terms, it is imperative to acknowledge and to explore the implications of the important associations between the rise in the incidence of melanomas and environmental factors such as our increasing exposure to artificial light, electromagnetic radiation, and photo-sensitizing chemicals added to many processed foods and a range of medicinal drugs. Our argument has been that these environmental factors contribute to the problem either by altering body chemistry to make it more susceptible to the admittedly harmful effects associated with irregular and excessive exposure to the sun, and/or acting directly, as in the case of electromagnetic radiation, as promoters of melanoma.

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Year:  1993        PMID: 8431532     DOI: 10.1007/bf00051715

Source DB:  PubMed          Journal:  Cancer Causes Control        ISSN: 0957-5243            Impact factor:   2.506


  22 in total

1.  Geographic variation in breast cancer mortality in the United States: a hypothesis involving exposure to solar radiation.

Authors:  F C Garland; C F Garland; E D Gorham; J F Young
Journal:  Prev Med       Date:  1990-11       Impact factor: 4.018

2.  Myocardial infarction is inversely associated with plasma 25-hydroxyvitamin D3 levels: a community-based study.

Authors:  R Scragg; R Jackson; I M Holdaway; T Lim; R Beaglehole
Journal:  Int J Epidemiol       Date:  1990-09       Impact factor: 7.196

3.  Effect of dietary lipid on UV light carcinogenesis in the hairless mouse.

Authors:  V E Reeve; M Matheson; G E Greenoak; P J Canfield; C Boehm-Wilcox; C H Gallagher
Journal:  Photochem Photobiol       Date:  1988-11       Impact factor: 3.421

4.  60-Hz electric-field effects on pineal melatonin rhythms: time course for onset and recovery.

Authors:  B W Wilson; E K Chess; L E Anderson
Journal:  Bioelectromagnetics       Date:  1986       Impact factor: 2.010

5.  The aetiology of melanoma.

Authors: 
Journal:  Lancet       Date:  1981-01-31       Impact factor: 79.321

6.  Possible cancer hazard associated with 5-methoxypsoralen in suntan preparations.

Authors:  M J Ashwood-Smith
Journal:  Br Med J       Date:  1979-11-03

7.  Sunscreens suppress cutaneous vitamin D3 synthesis.

Authors:  L Y Matsuoka; L Ide; J Wortsman; J A MacLaughlin; M F Holick
Journal:  J Clin Endocrinol Metab       Date:  1987-06       Impact factor: 5.958

8.  Magnetic field of the earth as additional zeitgeber for endogenous rhythms?

Authors:  G Cremer-Bartels; K Krause; G Mitoskas; D Brodersen
Journal:  Naturwissenschaften       Date:  1984-11

9.  Malignant melanoma and oral contraceptive use among women in California.

Authors:  V Beral; S Ramcharan; R Faris
Journal:  Br J Cancer       Date:  1977-12       Impact factor: 7.640

10.  Malignant melanoma: social status and outdoor work.

Authors:  J A Lee; D Strickland
Journal:  Br J Cancer       Date:  1980-05       Impact factor: 7.640

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