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Literature DB >> 8424751

Structural analysis of the human insulin-like growth factor-II P3 promoter.

Abstract

The expression of insulin-like growth factor-II (IGF-II) has been observed previously in many human cancers. The human IGF-II P3 promoter has been shown by others to give rise to abundant 6.0 kb and 2.2 kb fetal transcripts which are expressed in a variety of both paediatric and adult tumours. In order to determine the mechanism by which the P3 promoter is controlled, the promoter was analysed in cell lines using chloramphenicol acetyltransferase (CAT) assay and DNAase I footprinting techniques. The data indicated that P3 is a complex promoter involving at least nine transcription factor binding sites. Furthermore, high levels of 5-methylcytosine detected in the P3 promoter of HeLa genomic DNA suggest that IGF-II gene expression may also be influenced by DNA methylation.

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Year: 1993 PMID： 8424751 PMCID： PMC1132140 DOI： 10.1042/bj2890133

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

43 in total

1. High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines.

Authors: F Antequera; J Boyes; A Bird
Journal: Cell Date: 1990-08-10 Impact factor: 41.582

Review 2. A relational database of transcription factors.

Authors: D Ghosh
Journal: Nucleic Acids Res Date: 1990-04-11 Impact factor: 16.971

3. Transcription maps of polyoma virus-specific RNA: analysis by two-dimensional nuclease S1 gel mapping.

Authors: J Favaloro; R Treisman; R Kamen
Journal: Methods Enzymol Date: 1980 Impact factor: 1.600

4. Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter.

Authors: D A Melton; P A Krieg; M R Rebagliati; T Maniatis; K Zinn; M R Green
Journal: Nucleic Acids Res Date: 1984-09-25 Impact factor: 16.971

5. A promoter of the rat insulin-like growth factor II gene consists of minimal control elements.

Authors: T Evans; T DeChiara; A Efstratiadis
Journal: J Mol Biol Date: 1988-01-05 Impact factor: 5.469

6. Autocrine regulation of human tumor cell proliferation by insulin-like growth factor II: an in-vitro model.

Authors: M A Thompson; A J Cox; R H Whitehead; H A Jonas
Journal: Endocrinology Date: 1990-06 Impact factor: 4.736

7. A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting.

Authors: T M DeChiara; A Efstratiadis; E J Robertson
Journal: Nature Date: 1990-05-03 Impact factor: 49.962

8. Differential expression of the human insulin-like growth factor II gene. Characterization of the IGF-II mRNAs and an mRNA encoding a putative IGF-II-associated protein.

Authors: P de Pagter-Holthuizen; M Jansen; R A van der Kammen; F M van Schaik; J S Sussenbach
Journal: Biochim Biophys Acta Date: 1988-09-07

Structural analysis of the human insulin-like growth factor-II P3 promoter.

1. High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines.

Review 2. A relational database of transcription factors.

3. Transcription maps of polyoma virus-specific RNA: analysis by two-dimensional nuclease S1 gel mapping.

4. Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter.

5. A promoter of the rat insulin-like growth factor II gene consists of minimal control elements.

6. Autocrine regulation of human tumor cell proliferation by insulin-like growth factor II: an in-vitro model.

7. A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting.

8. Differential expression of the human insulin-like growth factor II gene. Characterization of the IGF-II mRNAs and an mRNA encoding a putative IGF-II-associated protein.

9. Expression of insulin-like growth factor-II transcripts in Wilms' tumour.

10. Insulin-like growth factor-II gene expression in Wilms' tumour and embryonic tissues.

1. Transactivation of mouse insulin-like growth factor II (IGF-II) gene promoters by the AP-1 complex.

2. IGF-II promoter methylation and ovarian cancer prognosis.

3. Similarity and variation in the insulin-like growth factor 2 - H19 locus in primates.

4. Regulation of Insulin-Like Growth Factor 2 by Oocyte-Secreted Factors in Primary Human Granulosa Cells.

5. The complex genetics of human insulin-like growth factor 2 are not reflected in public databases.