Literature DB >> 8424449

Eosinophils are the major source of transforming growth factor-beta 1 in nodular sclerosing Hodgkin's disease.

M Kadin1, J Butmarc, A Elovic, D Wong.   

Abstract

Transforming growth factor-beta 1 (TGF-beta 1) is a multifunctional cytokine which promotes fibroblast growth and collagen synthesis, but suppresses growth and differentiation of immune lymphocytes and killer cells. Immunohistochemical detection of TGF-beta 1 in Hodgkin's disease (HD) has been shown to correlate with the histologic feature of nodular sclerosis, which is associated with a favorable prognosis (American Journal of Pathology 1990, 136:1209). In that study, TGF-beta 1 was localized mainly at the margins of broad collagen bands (presumably sites of new collagen synthesis) and in areas containing numerous Hodgkin/Reed-Sternberg cells (H/RS). In these areas, TGF-beta 1 protein was found on the membrane and occasionally within the cytoplasm of H/RS cells. To determine whether TGF-beta 1 is synthesized by H/RS cells or secondarily bound to their membrane and sometimes internalized, we performed in situ hybridization (ISH) using 1.5 Kb 35S-labeled anti-sense and sense RNA probes to TGF-beta 1. Paraffin-embedded tissues of 10 cases from all histologic types of HD were examined. Somewhat unexpectedly, the major site of TGF-beta 1 mRNA was in eosinophils; TGF-beta 1 mRNA was not detected in H/RS cells. TGF-beta 1 mRNA was found in eosinophils in all cases of nodular sclerosis but not in other types of HD, despite the presence of numerous eosinophils in mixed cellularity cases. The presence of TGF-beta 1 mRNA coincided with immunohistochemical detection of TGF-beta 1 protein using antibody CC (1-30). These results confirm the role of TGF-beta 1 in the histogenesis of nodular sclerosing HD and indicate that eosinophils are the major source of TGF-beta 1 in this type of HD.

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Year:  1993        PMID： 8424449      PMCID： PMC1886832     

Source DB:  PubMed          Journal:  Am J Pathol        ISSN： 0002-9440            Impact factor:   4.307


  31 in total

1.  Eosinophils from patients with blood eosinophilia express transforming growth factor beta 1.

Authors:  D T Wong; A Elovic; K Matossian; N Nagura; J McBride; M Y Chou; J R Gordon; T H Rand; S J Galli; P F Weller
Journal:  Blood       Date:  1991-11-15       Impact factor: 22.113

2.  Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

Authors:  A B Roberts; M B Sporn; R K Assoian; J M Smith; N S Roche; L M Wakefield; U I Heine; L A Liotta; V Falanga; J H Kehrl
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

3.  Malignant lymphoma, histiocytic type with sclerosis (sclerosing reticulum cell sarcoma).

Authors:  A Rosas-Uribe; H Rappaport
Journal:  Cancer       Date:  1972-04       Impact factor: 6.860

4.  Correlation of histopathology with other prognostic indicators in Hodgkin's disease.

Authors:  A R Keller; H S Kaplan; R J Lukes; H Rappaport
Journal:  Cancer       Date:  1968-09       Impact factor: 6.860

5.  Extracellular deposition of eosinophil granule major basic protein in lymph nodes of patients with Hodgkin's disease.

Authors:  J H Butterfield; G M Kephart; P M Banks; G J Gleich
Journal:  Blood       Date:  1986-12       Impact factor: 22.113

6.  Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells.

Authors:  R Derynck; J A Jarrett; E Y Chen; D H Eaton; J R Bell; R K Assoian; A B Roberts; M B Sporn; D V Goeddel
Journal:  Nature       Date:  1985 Aug 22-28       Impact factor: 49.962

7.  The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells.

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Journal:  Blood       Date:  1985-10       Impact factor: 22.113

8.  Effects of transforming growth factor beta on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsiveness.

Authors:  A H Rook; J H Kehrl; L M Wakefield; A B Roberts; M B Sporn; D B Burlington; H C Lane; A S Fauci
Journal:  J Immunol       Date:  1986-05-15       Impact factor: 5.422

9.  Transforming growth factor beta is an important immunomodulatory protein for human B lymphocytes.

Authors:  J H Kehrl; A B Roberts; L M Wakefield; S Jakowlew; M B Sporn; A S Fauci
Journal:  J Immunol       Date:  1986-12-15       Impact factor: 5.422

10.  Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

Authors:  J H Kehrl; L M Wakefield; A B Roberts; S Jakowlew; M Alvarez-Mon; R Derynck; M B Sporn; A S Fauci
Journal:  J Exp Med       Date:  1986-05-01       Impact factor: 14.307
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  18 in total

1.  Retrospective analysis of the prognostic role of tissue eosinophil and mast cells in Hodgkin's lymphoma.

Authors:  Katalin Keresztes; Zoltan Szollosi; Zsofia Simon; Ilona Tarkanyi; Zoltan Nemes; Arpad Illes
Journal:  Pathol Oncol Res       Date:  2007-10-07       Impact factor: 3.201

Review 2.  Insights into the molecular roles of heparan sulfate proteoglycans (HSPGs-syndecans) in autocrine and paracrine growth factor signaling in the pathogenesis of Hodgkin's lymphoma.

Authors:  Rajendra Gharbaran
Journal:  Tumour Biol       Date:  2016-06-18

Review 3.  Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases.

Authors:  D R Lucey; M Clerici; G M Shearer
Journal:  Clin Microbiol Rev       Date:  1996-10       Impact factor: 26.132

Review 4.  Alpha 4 integrin-induced cytokine production and eosinophil function.

Authors:  D H Broide
Journal:  Springer Semin Immunopathol       Date:  1995

5.  Human eosinophils regulate human lung- and skin-derived fibroblast properties in vitro: a role for transforming growth factor beta (TGF-beta).

Authors:  F Levi-Schaffer; E Garbuzenko; A Rubin; R Reich; D Pickholz; P Gillery; H Emonard; A Nagler; F A Maquart
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-17       Impact factor: 11.205

6.  Intercellular cell adhesion molecule-1, vascular cell adhesion molecule-1, and regulated on activation normal T cell expressed and secreted are expressed by human breast carcinoma cells and support eosinophil adhesion and activation.

Authors:  S Ali; J Kaur; K D Patel
Journal:  Am J Pathol       Date:  2000-07       Impact factor: 4.307

7.  The direct effect of interferon-gamma on human eosinophilic leukemia cell lines: the induction of interleukin-5 mRNA and the presence of an interferon-gamma receptor.

Authors:  T Ishizuka; K Morita; T Hisada; T Ishizuka; S Ando; M Adachi; K Dobashi; M Mori
Journal:  Inflammation       Date:  1996-04       Impact factor: 4.092

8.  Critical roles for IL-4, IL-5, and eosinophils in chronic skin allograft rejection.

Authors:  A Le Moine; V Flamand; F X Demoor; J C Noël; M Surquin; R Kiss; M A Nahori; M Pretolani; M Goldman; D Abramowicz
Journal:  J Clin Invest       Date:  1999-06       Impact factor: 14.808

9.  Constitutive expression of tenascin in T-dependent zones of human lymphoid tissues.

Authors:  M Chilosi; M Lestani; A Benedetti; L Montagna; S Pedron; A Scarpa; F Menestrina; S Hirohashi; G Pizzolo; G Semenzato
Journal:  Am J Pathol       Date:  1993-11       Impact factor: 4.307

10.  Eosinophils expressing heparin-binding EGF-like growth factor mRNA localize around lung microvessels in pulmonary hypertension.

Authors:  P P Powell; M Klagsbrun; J A Abraham; R C Jones
Journal:  Am J Pathol       Date:  1993-09       Impact factor: 4.307
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