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Literature DB >> 8421705

Pleiotrophin transforms NIH 3T3 cells and induces tumors in nude mice.

Abstract

The pleiotrophin (PTN) gene (Ptn) encodes an 18-kDa protein that is highly conserved among mammalian species and that functions as a weak mitogen and promotes neurite-outgrowth activity in vitro. To further investigate the role PTN plays in regulating cell growth, we overexpressed the bovine PTN cDNA and now show that PTN phenotypically transforms NIH 3T3 cells, as evidenced by increased cell number at confluence, focus formation, anchorage-independent growth, and tumor formation in the nude mouse. The results demonstrate that the Ptn gene has the potential to regulate NIH 3T3 cell growth and suggest that PTN may influence abnormal cell growth in vivo.

Entities: Disease Gene Species

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Year: 1993 PMID： 8421705 PMCID： PMC45727 DOI： 10.1073/pnas.90.2.679

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

26 in total

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31 in total

1. Pleiotrophin regulates serine phosphorylation and the cellular distribution of beta-adducin through activation of protein kinase C.

Authors: Harold Pariser; Gonzalo Herradon; Laura Ezquerra; Pablo Perez-Pinera; Thomas F Deuel
Journal: Proc Natl Acad Sci U S A Date: 2005-08-22 Impact factor: 11.205

2. Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta.

Authors: K Meng; A Rodriguez-Peña; T Dimitrov; W Chen; M Yamin; M Noda; T F Deuel
Journal: Proc Natl Acad Sci U S A Date: 2000-03-14 Impact factor: 11.205

3. Pathogenic role and therapeutic potential of pleiotrophin in mouse models of ocular vascular disease.

Authors: Weiwen Wang; Michelle E LeBlanc; Xiuping Chen; Ping Chen; Yanli Ji; Megan Brewer; Hong Tian; Samantha R Spring; Keith A Webster; Wei Li
Journal: Angiogenesis Date: 2017-04-26 Impact factor: 9.596

4. Secretion of pleiotrophin stimulates breast cancer progression through remodeling of the tumor microenvironment.

Authors: Yunchao Chang; Masahiko Zuka; Pablo Perez-Pinera; Aurora Astudillo; Joanne Mortimer; James R Berenson; Thomas F Deuel
Journal: Proc Natl Acad Sci U S A Date: 2007-06-19 Impact factor: 11.205

5. Structure and phylogenetic analysis of an endogenous retrovirus inserted into the human growth factor gene pleiotrophin.

Authors: A M Schulte; A Wellstein
Journal: J Virol Date: 1998-07 Impact factor: 5.103