Literature DB >> 20890627

Localization of D-serine and serine racemase in neurons and neuroglias in mouse brain.

Xiaohui Ding1, Ning Ma, Masato Nagahama, Kumiko Yamada, Reiji Semba.   

Abstract

D-serine is a novel candidate for an intrinsic ligand for the glycine site of N-methyl-D-aspartate (NMDA) receptors in mammalian brain. D-serine and serine racemase, which produces D-serine from L-serine, have long been presumed to be localized in astrocytes. However, we have reported that D-serine immunoreactivity was observed in neurons in rats. In the present study, the distributions of D-serine and serine racemase were investigated in combination with marker proteins for neurons, astrocytes and oligodendrocytes in mice. Immunoreactivities for D-serine and serine racemase were found in neurons and oligodendrocytes. These results suggest that D-serine can be produced in neurons as well as glias and used as a neurotransmitter, which control the synaptic function of NMDA receptors.

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Year:  2010        PMID： 20890627     DOI： 10.1007/s10072-010-0422-2

Source DB:  PubMed          Journal:  Neurol Sci        ISSN： 1590-1874            Impact factor:   3.307


  20 in total

1.  Expression of the mRNA and protein of serine racemase in primary cultures of rat neurons.

Authors:  Masanobu Yoshikawa; Kazuyuki Nakajima; Naoko Takayasu; Setsuko Noda; Yuichi Sato; Mitsuru Kawaguchi; Tetsuo Oka; Hiroyuki Kobayashi; Atsushi Hashimoto
Journal:  Eur J Pharmacol       Date:  2006-08-22       Impact factor: 4.432

2.  D-serine as a neuromodulator: regional and developmental localizations in rat brain glia resemble NMDA receptors.

Authors:  M J Schell; R O Brady; M E Molliver; S H Snyder
Journal:  J Neurosci       Date:  1997-03-01       Impact factor: 6.167

3.  Purification of serine racemase: biosynthesis of the neuromodulator D-serine.

Authors:  H Wolosker; K N Sheth; M Takahashi; J P Mothet; R O Brady; C D Ferris; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1999-01-19       Impact factor: 11.205

4.  Changes in D-serine levels and localization during postnatal development of the rat vestibular nuclei.

Authors:  Julien Puyal; Magalie Martineau; Jean-Pierre Mothet; Marie-Thérèse Nicolas; Jacqueline Raymond
Journal:  J Comp Neurol       Date:  2006-08-01       Impact factor: 3.215

5.  Immunohistochemical evidences for localization and production of D-serine in some neurons in the rat brain.

Authors:  E Yasuda; N Ma; R Semba
Journal:  Neurosci Lett       Date:  2001-02-16       Impact factor: 3.046

6.  Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission.

Authors:  H Wolosker; S Blackshaw; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1999-11-09       Impact factor: 11.205

7.  D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor.

Authors:  J P Mothet; A T Parent; H Wolosker; R O Brady; D J Linden; C D Ferris; M A Rogawski; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  2000-04-25       Impact factor: 11.205

8.  Glial uptake of intracerebroventricularly injected D-serine in the rat brain: an immunocytochemical study.

Authors:  K Wako; N Ma; T Shiroyama; R Semba
Journal:  Neurosci Lett       Date:  1995-02-13       Impact factor: 3.046

9.  The serine racemase mRNA is predominantly expressed in rat brain neurons.

Authors:  Masanobu Yoshikawa; Naoko Takayasu; Atsushi Hashimoto; Yuichi Sato; Raita Tamaki; Hideo Tsukamoto; Hiroyuki Kobayashi; Setsuko Noda
Journal:  Arch Histol Cytol       Date:  2007-07

10.  Endogenous D-serine in rat brain: N-methyl-D-aspartate receptor-related distribution and aging.

Authors:  A Hashimoto; T Nishikawa; T Oka; K Takahashi
Journal:  J Neurochem       Date:  1993-02       Impact factor: 5.372
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  15 in total

1.  Cell selective conditional null mutations of serine racemase demonstrate a predominate localization in cortical glutamatergic neurons.

Authors:  Michael A Benneyworth; Yan Li; Alo C Basu; Vadim Y Bolshakov; Joseph T Coyle
Journal:  Cell Mol Neurobiol       Date:  2012-02-24       Impact factor: 5.046

2.  Contribution of Astroglial Cx43 Hemichannels to the Modulation of Glutamatergic Currents by D-Serine in the Mouse Prefrontal Cortex.

Authors:  Claire Meunier; Nan Wang; Chenju Yi; Glenn Dallerac; Pascal Ezan; Annette Koulakoff; Luc Leybaert; Christian Giaume
Journal:  J Neurosci       Date:  2017-08-11       Impact factor: 6.167

3.  Neuronal D-serine regulates dendritic architecture in the somatosensory cortex.

Authors:  Darrick T Balu; Joseph T Coyle
Journal:  Neurosci Lett       Date:  2012-04-12       Impact factor: 3.046

4.  D-serine and serine racemase are localized to neurons in the adult mouse and human forebrain.

Authors:  Darrick T Balu; Shunsuke Takagi; Matthew D Puhl; Michael A Benneyworth; Joseph T Coyle
Journal:  Cell Mol Neurobiol       Date:  2014-01-17       Impact factor: 5.046

5.  Postsynaptic Serine Racemase Regulates NMDA Receptor Function.

Authors:  Jonathan M Wong; Oluwarotimi O Folorunso; Eden V Barragan; Cristina Berciu; Theresa L Harvey; Joseph T Coyle; Darrick T Balu; John A Gray
Journal:  J Neurosci       Date:  2020-11-06       Impact factor: 6.167

Review 6.  The NMDA Receptor and Schizophrenia: From Pathophysiology to Treatment.

Authors:  D T Balu
Journal:  Adv Pharmacol       Date:  2016-03-04

7.  Serine Racemase Expression by Striatal Neurons.

Authors:  Shunsuke Takagi; Matthew D Puhl; Thea Anderson; Darrick T Balu; Joseph T Coyle
Journal:  Cell Mol Neurobiol       Date:  2020-05-22       Impact factor: 5.046

Review 8.  Molecular approaches for manipulating astrocytic signaling in vivo.

Authors:  Alison X Xie; Jeremy Petravicz; Ken D McCarthy
Journal:  Front Cell Neurosci       Date:  2015-04-21       Impact factor: 5.505

9.  Increased excitation-inhibition balance and loss of GABAergic synapses in the serine racemase knockout model of NMDA receptor hypofunction.

Authors:  Shekib A Jami; Scott Cameron; Jonathan M Wong; Emily R Daly; A Kimberley McAllister; John A Gray
Journal:  J Neurophysiol       Date:  2021-05-26       Impact factor: 2.714

10.  Computational model of neuron-astrocyte interactions during focal seizure generation.

Authors:  Davide Reato; Mario Cammarota; Lucas C Parra; Giorgio Carmignoto
Journal:  Front Comput Neurosci       Date:  2012-10-10       Impact factor: 2.380
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