Literature DB >> 8415671

Salivary gland extracts from the deerfly contain a potent inhibitor of platelet aggregation.

S A Grevelink1, D E Youssef, J Loscalzo, E A Lerner.   

Abstract

Salivary gland extracts of the deerfly contain a potent inhibitor of platelet aggregation, which assists the insect in obtaining a blood meal. The extract prevents platelet aggregation induced by ADP, thrombin, and collagen and inhibits fibrinogen binding to the glycoprotein IIb/IIIa receptor on platelets. The active component in deerfly salivary gland extract appears to be a protein that is comparatively more potent than the disintegrins present in viper venoms. Isolation and characterization of this protein may provide different directions in therapeutics and studies of normal platelet physiology.

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Year:  1993        PMID： 8415671      PMCID： PMC47520          DOI： 10.1073/pnas.90.19.9155

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  16 in total

1.  Assay of inorganic and organic phosphorus in the 0.1-5 nanomole range.

Authors:  H H Hess; J E Derr
Journal:  Anal Biochem       Date:  1975-02       Impact factor: 3.365

2.  THE AGGREGATION OF BLOOD PLATELETS.

Authors:  G V BORN; M J CROSS
Journal:  J Physiol       Date:  1963-08       Impact factor: 5.182

Review 3.  Disintegrins: a family of integrin inhibitory proteins from viper venoms.

Authors:  R J Gould; M A Polokoff; P A Friedman; T F Huang; J C Holt; J J Cook; S Niewiarowski
Journal:  Proc Soc Exp Biol Med       Date:  1990-11

4.  Isolation of maxadilan, a potent vasodilatory peptide from the salivary glands of the sand fly Lutzomyia longipalpis.

Authors:  E A Lerner; J M Ribeiro; R J Nelson; M R Lerner
Journal:  J Biol Chem       Date:  1991-06-15       Impact factor: 5.157

5.  Leeches, snakes, ticks, and vampire bats in today's cardiovascular drug development.

Authors:  N U Bang
Journal:  Circulation       Date:  1991-07       Impact factor: 29.690

6.  Ixodes dammini: evidence for salivary prostacyclin secretion.

Authors:  J M Ribeiro; G T Makoul; D R Robinson
Journal:  J Parasitol       Date:  1988-12       Impact factor: 1.276

7.  Tick anticoagulant peptide (TAP) is a novel inhibitor of blood coagulation factor Xa.

Authors:  L Waxman; D E Smith; K E Arcuri; G P Vlasuk
Journal:  Science       Date:  1990-05-04       Impact factor: 47.728

8.  von Willebrand protein facilitates platelet incorporation in polymerizing fibrin.

Authors:  J Loscalzo; A Inbal; R I Handin
Journal:  J Clin Invest       Date:  1986-10       Impact factor: 14.808

9.  Salivary apyrase of Aedes aegypti: characterization and secretory fate.

Authors:  J M Ribeiro; J J Sarkis; P A Rossignol; A Spielman
Journal:  Comp Biochem Physiol B       Date:  1984

10.  Two platelet aggregation inhibitors in tsetse (Glossina) saliva with studies of roles of thrombin and citrate in in vitro platelet aggregation.

Authors:  M J Mant; K R Parker
Journal:  Br J Haematol       Date:  1981-08       Impact factor: 6.998
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  2 in total

1.  Anti-thrombosis repertoire of blood-feeding horsefly salivary glands.

Authors:  Dongying Ma; Yipeng Wang; Hailong Yang; Jing Wu; Shu An; Li Gao; Xueqing Xu; Ren Lai
Journal:  Mol Cell Proteomics       Date:  2009-06-16       Impact factor: 5.911

2.  Identification of a tsetse fly salivary protein with dual inhibitory action on human platelet aggregation.

Authors:  Guy Caljon; Karin De Ridder; Patrick De Baetselier; Marc Coosemans; Jan Van Den Abbeele
Journal:  PLoS One       Date:  2010-03-23       Impact factor: 3.240
  2 in total

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