Literature DB >> 2040631

Isolation of maxadilan, a potent vasodilatory peptide from the salivary glands of the sand fly Lutzomyia longipalpis.

E A Lerner1, J M Ribeiro, R J Nelson, M R Lerner.   

Abstract

Blood feeding by the sand fly Lutzomyia longipalpis is aided by the presence of a vasodilator in its salivary glands. This novel vasodilator has been isolated by reversed-phase high-performance liquid chromatography. Ten nanograms of the vasodilator are present in the extract of a pair of sand fly salivary glands. It has 500 times the vasodilatory activity of calcitonin gene-related peptide, previously the most potent vasodilator peptide known. This novel peptide is thus called maxadilan.

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Year:  1991        PMID： 2040631

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  55 in total

Review 1.  An insight into the sialome of blood-feeding Nematocera.

Authors:  José M C Ribeiro; Ben J Mans; Bruno Arcà
Journal:  Insect Biochem Mol Biol       Date:  2010-08-20       Impact factor: 4.714

Review 2.  Maxadilan, a PAC1 receptor agonist from sand flies.

Authors:  Ethan A Lerner; Aurel O Iuga; Vemuri B Reddy
Journal:  Peptides       Date:  2007-06-28       Impact factor: 3.750

3.  The protein LJM 111 from Lutzomyia longipalpis salivary gland extract (SGE) accounts for the SGE-inhibitory effects upon inflammatory parameters in experimental arthritis model.

Authors:  Renata Grespan; Henrique P Lemos; Vanessa Carregaro; Waldiceu A Verri; Fabricio O Souto; Carlo J F de Oliveira; Clarissa Teixeira; José Marcos Ribeiro; Jesus G Valenzuela; Fernando Q Cunha
Journal:  Int Immunopharmacol       Date:  2012-02-21       Impact factor: 4.932

Review 4.  What's behind a sand fly bite? The profound effect of sand fly saliva on host hemostasis, inflammation and immunity.

Authors:  Maha Abdeladhim; Shaden Kamhawi; Jesus G Valenzuela
Journal:  Infect Genet Evol       Date:  2014-08-10       Impact factor: 3.342

Review 5.  Smuggling across the border: how arthropod-borne pathogens evade and exploit the host defense system of the skin.

Authors:  Quentin Bernard; Benoit Jaulhac; Nathalie Boulanger
Journal:  J Invest Dermatol       Date:  2013-12-28       Impact factor: 8.551

6.  Pituitary adenylate cyclase-activating peptide receptor 1 mediates anti-inflammatory effects in allergic airway inflammation in mice.

Authors:  H D Lauenstein; D Quarcoo; L Plappert; C Schleh; M Nassimi; C Pilzner; S Rochlitzer; P Brabet; T Welte; H G Hoymann; N Krug; M Müller; E A Lerner; A Braun; D A Groneberg
Journal:  Clin Exp Allergy       Date:  2010-11-09       Impact factor: 5.018

7.  Maxadilan, the Lutzomyia longipalpis vasodilator, drives plasma leakage via PAC1-CXCR1/2-pathway.

Authors:  Erik Svensjö; Elvira M Saraiva; Rafael Silveira Amendola; Christina Barja-Fidalgo; Marcelo T Bozza; Ethan A Lerner; Mauro M Teixeira; Julio Scharfstein
Journal:  Microvasc Res       Date:  2011-10-19       Impact factor: 3.514

8.  Novel family of insect salivary inhibitors blocks contact pathway activation by binding to polyphosphate, heparin, and dextran sulfate.

Authors:  Patricia H Alvarenga; Xueqing Xu; Fabiano Oliveira; Andrezza C Chagas; Clarissa R Nascimento; Ivo M B Francischetti; Maria A Juliano; Luiz Juliano; Julio Scharfstein; Jesus G Valenzuela; José M C Ribeiro; John F Andersen
Journal:  Arterioscler Thromb Vasc Biol       Date:  2013-10-03       Impact factor: 8.311

9.  Identification of a tsetse fly salivary protein with dual inhibitory action on human platelet aggregation.

Authors:  Guy Caljon; Karin De Ridder; Patrick De Baetselier; Marc Coosemans; Jan Van Den Abbeele
Journal:  PLoS One       Date:  2010-03-23       Impact factor: 3.240

10.  Cooperative blood-feeding and the function and implications of feeding aggregations in the sand fly, Lutzomyia longipalpis (Diptera: Psychodidae).

Authors:  Frédéric Tripet; Simon Clegg; Dia-Eldin Elnaiem; Richard D Ward
Journal:  PLoS Negl Trop Dis       Date:  2009-08-18
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