Literature DB >> 841324

25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol: conversion impaired by systemic metabolic acidosis.

S W Lee, J Russell, L V Avioli.   

Abstract

An acute systemic acidosis in vitamin D depleted rats that was induced by ammonium chlroide feeding resulted in defective biological hydroxylation of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol. Impaired enzymatic hydroxylation occurred despite the presence of either hypophosphatemia or hypocalcemia. The data suggest that acidosis interfers with the adaptive enzymatic control of 25-hydroxycholecalciferol metabolism in the vitamin D depleted state.

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Year:  1977        PMID： 841324     DOI： 10.1126/science.841324

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  24 in total

1.  Bone maturation in the vitamin D, phosphate deficient rat and the response to acid loading.

Authors:  J E Russell; L V Avioli
Journal:  Calcif Tissue Int       Date:  1979-07-03       Impact factor: 4.333

2.  [Metabolic long-term complications after urinary diversion].

Authors:  R Stein; C Ziesel; S Frees; J W Thüroff
Journal:  Urologe A       Date:  2012-04       Impact factor: 0.639

3.  Sustained activation of renal N-methyl-D-aspartate receptors decreases vitamin D synthesis: a possible role for glutamate on the onset of secondary HPT.

Authors:  Eva Parisi; Milica Bozic; Mercé Ibarz; Sara Panizo; Petya Valcheva; Blai Coll; Elvira Fernández; José M Valdivielso
Journal:  Am J Physiol Endocrinol Metab       Date:  2010-09-07       Impact factor: 4.310

4.  Interactions between vitamin D deficiency and phosphorus depletion in the rat.

Authors:  N Brautbar; M W Walling; J W Coburn
Journal:  J Clin Invest       Date:  1979-02       Impact factor: 14.808

5.  Acquired alterations in vitamin D metabolism in the acidotic state.

Authors:  D T Baran; S W Lee; O D Jo; L V Avioli
Journal:  Calcif Tissue Int       Date:  1982-03       Impact factor: 4.333

6.  Effects of changing hydrogen ion, carbonic acid, and bicarbonate concentrations on bone resorption in vitro.

Authors:  J H Dominguez; L G Raisz
Journal:  Calcif Tissue Int       Date:  1979-11       Impact factor: 4.333

7.  Attainment and maintenance of normal stature with alkali therapy in infants and children with classic renal tubular acidosis.

Authors:  E McSherry; R C Morris
Journal:  J Clin Invest       Date:  1978-02       Impact factor: 14.808

Review 8.  Bladder, bowel and bones--skeletal changes after intestinal urinary diversion.

Authors:  Alexander Roosen; Elmar W Gerharz; Stefan Roth; Christopher R J Woodhouse
Journal:  World J Urol       Date:  2004-08-13       Impact factor: 4.226

9.  Metabolic acidosis suppresses 25-hydroxyvitamin in D3-1alpha-hydroxylase in the rat kidney. Distinct site and mechanism of action.

Authors:  H Kawashima; J A Kraut; K Kurokawa
Journal:  J Clin Invest       Date:  1982-07       Impact factor: 14.808

10.  Zinc bone loss in chronic renal failure and chronic metabolic acidosis.

Authors:  A Caldas; M J Richard; S Maniar; D Laouari; M Dechaux; A Favier; C Kleinknecht
Journal:  Biol Trace Elem Res       Date:  1992 Jan-Mar       Impact factor: 3.738
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