Literature DB >> 6805921

Acquired alterations in vitamin D metabolism in the acidotic state.

D T Baran, S W Lee, O D Jo, L V Avioli.   

Abstract

Classic (type I) renal tubular acidosis in children in attended by growth retardation and rickets, abnormalities that can be corrected by alkali therapy alone. We have employed the NH4Cl-treated rachitic chick as a model to investigate vitamin D metabolism in the acidotic state. NH4Cl ingestion for 96 h was associated with a rise in serum calcium, a significant decrease in blood pH (7.42 +/- 0.08 vs 7.30 +/- 0.08, P less than 0.005), decreased [3H]1,25(OH)2D3 following [3H]25OHD D3 injections, and enhanced metabolic clearance of administered [3H]1,25(OH)2D3. The data collectively suggest that metabolic acidosis in the chick alters the production and degradation of 1,25(OH)2D3.

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Year:  1982        PMID： 6805921     DOI： 10.1007/BF02411228

Source DB:  PubMed          Journal:  Calcif Tissue Int        ISSN： 0171-967X            Impact factor:   4.333


  30 in total

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Journal:  AMA J Dis Child       Date:  1956-05

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Authors:  E Spanos; J W Pike; M R Haussler; K W Colston; I M Evans; A M Goldner; T A McCain; I MacIntyre
Journal:  Life Sci       Date:  1976-12-01       Impact factor: 5.037

3.  Vitamin D metabolism: physiological regulation in egg-laying Japanese quail.

Authors:  A D Kenny
Journal:  Am J Physiol       Date:  1976-06

4.  Regulation of 25-hydroxyvitamin D3-1-hydroxylase in vivo.

Authors:  H L Henry; R J Midgett; A W Norman
Journal:  J Biol Chem       Date:  1974-12-10       Impact factor: 5.157

5.  Treatment of osteomalacia of renal tubular acidosis by sodium bicarbonate alone.

Authors:  P Richards; M J Chamberlain; O M Wrong
Journal:  Lancet       Date:  1972-11-11       Impact factor: 79.321

6.  Measurement of total calcium in serum by atomic absorption spectrophotometry, with use of a strontium internal reference.

Authors:  J Pybus; F J Feldman; G N Bowers
Journal:  Clin Chem       Date:  1970-12       Impact factor: 8.327

7.  Vitamin D metabolism in Japanese quail: gonadal hormones and dietary calcium effects.

Authors:  S N Baksi; A D Kenny
Journal:  Am J Physiol       Date:  1978-06

8.  Attainment and maintenance of normal stature with alkali therapy in infants and children with classic renal tubular acidosis.

Authors:  E McSherry; R C Morris
Journal:  J Clin Invest       Date:  1978-02       Impact factor: 14.808

9.  The effect of induced metabolic acidosis on vitamin D3 metabolism in rachitic chicks.

Authors:  B Sauveur; M Garabedian; C Fellot; P Mongin; S Balsan
Journal:  Calcif Tissue Res       Date:  1977-06-28

10.  Lack of effect of calcitonin on the regulation of vitamin D metabolism in the rat.

Authors:  R Lorenc; Y Tanaka; H F DeLuca; G Jones
Journal:  Endocrinology       Date:  1977-02       Impact factor: 4.736
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  4 in total

1.  Growth failure associated with medullary sponge kidney, due to incomplete renal tubular acidosis type 1.

Authors:  T Sluysmans; J P Vanoverschelde; P Malvaux
Journal:  Eur J Pediatr       Date:  1987-01       Impact factor: 3.183

2.  Chronic metabolic acidosis increases the serum concentration of 1,25-dihydroxyvitamin D in humans by stimulating its production rate. Critical role of acidosis-induced renal hypophosphatemia.

Authors:  R Krapf; R Vetsch; W Vetsch; H N Hulter
Journal:  J Clin Invest       Date:  1992-12       Impact factor: 14.808

3.  Acute metabolic acidosis stimulates 3H-25 hydroxyvitamin D production by the rachitic rat liver.

Authors:  M L Milne; D T Baran
Journal:  Calcif Tissue Int       Date:  1985-01       Impact factor: 4.333

4.  The effect of metabolic acidosis on vitamin D metabolites and bone histology in uremic rats.

Authors:  Y L Chan; E Savdie; R S Mason; S Posen
Journal:  Calcif Tissue Int       Date:  1985-03       Impact factor: 4.333
  4 in total

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