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Literature DB >> 8410025

The metabolic effects of limbic leucotomy in Gilles de la Tourette syndrome.

G V Sawle¹, A J Lees, N F Hymas, D J Brooks, R S Frackowiak.

Abstract

Regional cerebral oxygen metabolism was measured before and after limbic leucotomy in a patient with Gilles de la Tourette syndrome, obsessive compulsive disorder, and obsessional slowness. The preoperative scan showed hypermetabolism in the caudate nuclei, which normalised after operation. It is proposed that the beneficial effects of this operation on both tics and obsessive compulsive behaviour are mediated by disruption of abnormal neural activity in basal ganglia-thalamocortical loops.

Entities: Chemical Disease Species

Mesh：

Substances：
Oxygen

Year: 1993 PMID： 8410025 PMCID： PMC489741 DOI： 10.1136/jnnp.56.9.1016

Source DB: PubMed Journal: J Neurol Neurosurg Psychiatry ISSN： 0022-3050 Impact factor: 10.154

20 in total

1. The treatment of Gilles de la Tourette syndrome by limbic leucotomy.

Authors: M Robertson; M Doran; M Trimble; A J Lees
Journal: J Neurol Neurosurg Psychiatry Date: 1990-08 Impact factor: 10.154

Review 2. Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions.

Authors: G E Alexander; M D Crutcher; M R DeLong
Journal: Prog Brain Res Date: 1990 Impact factor: 2.453

3. Gilles de la tourette syndrome: studies with the fluorine-18-labeled fluorodeoxyglucose positron emission tomographic method.

Authors: T N Chase; N L Foster; P Fedio; R Brooks; L Mansi; R Kessler; G Di Chiro
Journal: Ann Neurol Date: 1984 Impact factor: 10.422

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Authors: J G Modell; J M Mountz; G C Curtis; J F Greden
Journal: J Neuropsychiatry Clin Neurosci Date: 1989 Impact factor: 2.198

5. The neurology of obsessional slowness.

Authors: N Hymas; A Lees; D Bolton; K Epps; D Head
Journal: Brain Date: 1991-10 Impact factor: 13.501

6. Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 15O and positron emission tomography: theory, procedure, and normal values.

Authors: R S Frackowiak; G L Lenzi; T Jones; J D Heather
Journal: J Comput Assist Tomogr Date: 1980-12 Impact factor: 1.826

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Authors: R Hassler; G Dieckmann
Journal: Rev Neurol (Paris) Date: 1970-08 Impact factor: 2.607

8. The inheritance of Gilles de la Tourette's syndrome and associated behaviors. Evidence for autosomal dominant transmission.

Authors: D L Pauls; J F Leckman
Journal: N Engl J Med Date: 1986-10-16 Impact factor: 91.245

Review 9. Neuroanatomy of Gilles de la Tourette's syndrome. Possible midbrain involvement.

Authors: O Devinsky
Journal: Arch Neurol Date: 1983-08

10. Tourette's syndrome: a neurochemical analysis of postmortem cortical brain tissue.

Authors: H S Singer; I H Hahn; E Krowiak; E Nelson; T Moran
Journal: Ann Neurol Date: 1990-04 Impact factor: 10.422

5 in total

Review 1. Invasive circuitry-based neurotherapeutics: stereotactic ablation and deep brain stimulation for OCD.

Authors: Benjamin D Greenberg; Scott L Rauch; Suzanne N Haber
Journal: Neuropsychopharmacology Date: 2010-01 Impact factor: 7.853

2. Changes in metabolism of cerebral glucose after stereotactic leukotomy for refractory obsessive-compulsive disorder: a case report.

Authors: F Biver; S Goldman; A François; C De La Porte; A Luxen; B Gribomont; F Lotstra
Journal: J Neurol Neurosurg Psychiatry Date: 1995-04 Impact factor: 10.154