Literature DB >> 8401586

Chromosomal distribution of 320 genes from a brain cDNA library.

M H Polymeropoulos1, H Xiao, J M Sikela, M Adams, J C Venter, C R Merril.   

Abstract

We have determined the chromosomal assignment of 320 brain expressed genes by studying the segregation of polymerase chain reaction (PCR) products in human rodent somatic cell hybrids and by genetically mapping polymorphic cDNAs using the CEPH (Centre d'Etude du Polymophisme Humaine) reference pedigrees and database. These mapped genes can function as markers on the physical map of the human genome, as well as serve as candidate disease gene loci. Distribution of these genes to the human chromosomes correlates well with the GC content of the chromosomes. However, the distribution of these genes does not correlate well with the cytogenetic length of each chromosome.

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Year:  1993        PMID： 8401586     DOI： 10.1038/ng0893-381

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  8 in total

1.  The TIGR gene indices: reconstruction and representation of expressed gene sequences.

Authors:  J Quackenbush; F Liang; I Holt; G Pertea; J Upton
Journal:  Nucleic Acids Res       Date:  2000-01-01       Impact factor: 16.971

2.  Regional assignment of human ESTs by whole-genome radiation hybrid mapping.

Authors:  P D Hayes; K Schmitt; H B Jones; G Gyapay; J Weissenbach; P N Goodfellow
Journal:  Mamm Genome       Date:  1996-06       Impact factor: 2.957

3.  Expansion of the pig comparative map by expressed sequence tags (EST) mapping.

Authors:  A K Fridolfsson; T Hori; A K Winterø; M Fredholm; M Yerle; A Robic; L Andersson; H Ellegren
Journal:  Mamm Genome       Date:  1997-12       Impact factor: 2.957

4.  Construction of a chromosome specific library of human MARs and mapping of matrix attachment regions on human chromosome 19.

Authors:  L G Nikolaev; T Tsevegiyn; S B Akopov; L K Ashworth; E D Sverdlov
Journal:  Nucleic Acids Res       Date:  1996-04-01       Impact factor: 16.971

Review 5.  Toward the complete genomic map and molecular pathology of human chromosome 4.

Authors:  O Riess; B Winkelmann; J T Epplen
Journal:  Hum Genet       Date:  1994-07       Impact factor: 4.132

6.  Expression of the gene encoding the matrix gla protein by mature osteoblasts in human fracture non-unions.

Authors:  D M Lawton; J G Andrew; D R Marsh; J A Hoyland; A J Freemont
Journal:  Mol Pathol       Date:  1999-04

7.  A comprehensive, high-resolution genomic transcript map of human skeletal muscle.

Authors:  S Bortoluzzi; L Rampoldi; B Simionati; R Zimbello; A Barbon; F d'Alessi; N Tiso; A Pallavicini; S Toppo; N Cannata; G Valle; G Lanfranchi; G A Danieli
Journal:  Genome Res       Date:  1998-08       Impact factor: 9.043

8.  Analysis of a human brain transcriptome map.

Authors:  Ping Qiu; Lawrence Benbow; Suxing Liu; Jonathan R Greene; Luquan Wang
Journal:  BMC Genomics       Date:  2002-04-16       Impact factor: 3.969
  8 in total

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