Literature DB >> 8397227

Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor on human thymocytes.

H K Dadi1, C M Roifman.   

Abstract

Interleukin-7 (IL-7) is a glycoprotein that regulates lymphocyte precursor growth and differentiation. However, the exact mechanism whereby the IL-7 receptor (IL-7R) mediates these cell growth signals remains unknown. One of the earliest metabolic events linked to mitogenic responses in other growth factor receptor systems is the activation of phosphatidylinositol-3 kinase (PI-3 kinase). We demonstrate here that ligation of the IL-7R results in dose- and time-dependent increases in PI-3 kinase activity. These results suggest that PI-3 kinase is involved in signal transduction via the IL-7R in human thymocytes.

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Year:  1993        PMID： 8397227      PMCID： PMC288304          DOI： 10.1172/JCI116736

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  26 in total

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Journal:  Biochem J       Date:  1987-10-01       Impact factor: 3.857

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Journal:  Cell       Date:  1987-09-25       Impact factor: 41.582

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Authors:  S A Courtneidge; A Heber
Journal:  Cell       Date:  1987-09-25       Impact factor: 41.582

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Authors:  S Takeda; S Gillis; R Palacios
Journal:  Proc Natl Acad Sci U S A       Date:  1989-03       Impact factor: 11.205

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Authors:  M Whitman; D R Kaplan; B Schaffhausen; L Cantley; T M Roberts
Journal:  Nature       Date:  1985 May 16-22       Impact factor: 49.962

6.  Transforming protein of avian sarcoma virus UR2 is associated with phosphatidylinositol kinase activity: possible role in tumorigenesis.

Authors:  I G Macara; G V Marinetti; P C Balduzzi
Journal:  Proc Natl Acad Sci U S A       Date:  1984-05       Impact factor: 11.205

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Authors:  M Whitman; C P Downes; M Keeler; T Keller; L Cantley
Journal:  Nature       Date:  1988-04-14       Impact factor: 49.962

8.  Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells.

Authors:  R G Goodwin; S Lupton; A Schmierer; K J Hjerrild; R Jerzy; W Clevenger; S Gillis; D Cosman; A E Namen
Journal:  Proc Natl Acad Sci U S A       Date:  1989-01       Impact factor: 11.205

9.  B cell precursor growth-promoting activity. Purification and characterization of a growth factor active on lymphocyte precursors.

Authors:  A E Namen; A E Schmierer; C J March; R W Overell; L S Park; D L Urdal; D Y Mochizuki
Journal:  J Exp Med       Date:  1988-03-01       Impact factor: 14.307

10.  Recombinant interleukin 7, pre-B cell growth factor, has costimulatory activity on purified mature T cells.

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Journal:  J Exp Med       Date:  1989-03-01       Impact factor: 14.307
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  9 in total

1.  Targeting oncogenic interleukin-7 receptor signalling with N-acetylcysteine in T cell acute lymphoblastic leukaemia.

Authors:  Marc R Mansour; Casie Reed; Amy R Eisenberg; Jen-Chieh Tseng; Jean-Claude Twizere; Sarah Daakour; Akinori Yoda; Scott J Rodig; Noa Tal; Chen Shochat; Alla Berezovskaya; Daniel J DeAngelo; Stephen E Sallan; David M Weinstock; Shai Izraeli; Andrew L Kung; Alex Kentsis; A Thomas Look
Journal:  Br J Haematol       Date:  2014-09-26       Impact factor: 6.998

2.  Interferon-α inhibits CD4 T cell responses to interleukin-7 and interleukin-2 and selectively interferes with Akt signaling.

Authors:  Thao P Nguyen; Doug A Bazdar; Joseph C Mudd; Michael M Lederman; Clifford V Harding; Gareth A Hardy; Scott F Sieg
Journal:  J Leukoc Biol       Date:  2015-03-17       Impact factor: 4.962

3.  Association of serum cytokines with colorectal polyp number and type in adult males.

Authors:  Sarah S Comstock; Diana Xu; Kari Hortos; Bruce Kovan; Sarah McCaskey; Dorothy R Pathak; Jenifer I Fenton
Journal:  Eur J Cancer Prev       Date:  2016-05       Impact factor: 2.497

4.  Shared gamma(c) subunit within the human interleukin-7 receptor complex. A molecular basis for the pathogenesis of X-linked severe combined immunodeficiency.

Authors:  S Y Lai; J Molden; M A Goldsmith
Journal:  J Clin Invest       Date:  1997-01-15       Impact factor: 14.808

Review 5.  PIP3 pathway in regulatory T cells and autoimmunity.

Authors:  Masaki Kashiwada; Ping Lu; Paul B Rothman
Journal:  Immunol Res       Date:  2007       Impact factor: 2.829

Review 6.  Regulation of T-cell responses by PTEN.

Authors:  Jodi L Buckler; Xiaohe Liu; Laurence A Turka
Journal:  Immunol Rev       Date:  2008-08       Impact factor: 12.988

7.  The loss of PTEN allows TCR alphabeta lineage thymocytes to bypass IL-7 and Pre-TCR-mediated signaling.

Authors:  Thijs J Hagenbeek; Marianne Naspetti; Fabrice Malergue; Fabien Garçon; Jacques A Nunès; Kitty B J M Cleutjens; Jan Trapman; Paul Krimpenfort; Hergen Spits
Journal:  J Exp Med       Date:  2004-09-27       Impact factor: 14.307

8.  Insulin-like growth factor induces phosphorylation of immunoreactive insulin receptor substrate and its association with phosphatidylinositol-3 kinase in human thymocytes.

Authors:  R Kooijman; J J Lauf; A C Kappers; G T Rijkers
Journal:  J Exp Med       Date:  1995-08-01       Impact factor: 14.307

9.  Potential implications of interleukin-7 in chronic wound healing.

Authors:  Annie Bartlett; Andrew J Sanders; Fiona Ruge; Keith G Harding; Wen G Jiang
Journal:  Exp Ther Med       Date:  2016-04-18       Impact factor: 2.447
  9 in total

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