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Literature DB >> 8396539

cDNA cloning and pharmacological characterization of an opioid receptor with high affinities for kappa-subtype-selective ligands.

M Nishi¹, H Takeshima, K Fukuda, S Kato, K Mori.

Abstract

The amino acid sequence of a rat opioid receptor, designated as ROR-D, has been deduced by cloning and sequencing the cDNA. The ROR-D expressed from the cDNA exhibits high affinities for ligands selective for the opioid receptor kappa-subtype and low affinities for ligands selective for the delta- and mu-subtypes. RNA blot hybridization analysis indicated that ROR-D mRNA is distributed in cerebrum and brainstem but not in cerebellum.

Entities: Gene Species

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Year: 1993 PMID： 8396539 DOI： 10.1016/0014-5793(93)80923-i

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

11 in total

1. Opioid receptors from a lower vertebrate (Catostomus commersoni): sequence, pharmacology, coupling to a G-protein-gated inward-rectifying potassium channel (GIRK1), and evolution.

Authors: M G Darlison; F R Greten; R J Harvey; H J Kreienkamp; T Stühmer; H Zwiers; K Lederis; D Richter
Journal: Proc Natl Acad Sci U S A Date: 1997-07-22 Impact factor: 11.205

2. The kappa-opioid receptor is primarily postsynaptic: combined immunohistochemical localization of the receptor and endogenous opioids.

Authors: U Arvidsson; M Riedl; S Chakrabarti; L Vulchanova; J H Lee; A H Nakano; X Lin; H H Loh; P Y Law; M W Wessendorf
Journal: Proc Natl Acad Sci U S A Date: 1995-05-23 Impact factor: 11.205

Review 3. Recent advances in molecular recognition and signal transduction of active peptides: receptors for opioid peptides.

Authors: B L Kieffer
Journal: Cell Mol Neurobiol Date: 1995-12 Impact factor: 5.046

10. kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system.

Authors: F Simonin; C Gavériaux-Ruff; K Befort; H Matthes; B Lannes; G Micheletti; M G Mattéi; G Charron; B Bloch; B Kieffer
Journal: Proc Natl Acad Sci U S A Date: 1995-07-18 Impact factor: 11.205

cDNA cloning and pharmacological characterization of an opioid receptor with high affinities for kappa-subtype-selective ligands.

1. Opioid receptors from a lower vertebrate (Catostomus commersoni): sequence, pharmacology, coupling to a G-protein-gated inward-rectifying potassium channel (GIRK1), and evolution.

2. The kappa-opioid receptor is primarily postsynaptic: combined immunohistochemical localization of the receptor and endogenous opioids.

Review 3. Recent advances in molecular recognition and signal transduction of active peptides: receptors for opioid peptides.

Review 4. Clinical pharmacokinetics of alfentanil, fentanyl and sufentanil. An update.

5. Dynorphins modulate DNA synthesis in fetal brain cell aggregates.

6. Kappa2 opioid receptors in limbic areas of the human brain are upregulated by cocaine in fatal overdose victims.

7. Affinity labeling mu opioid receptors with novel radioligands.

Review 8. Modulation of pain transmission by G-protein-coupled receptors.

9. Herpes simplex virus vector-mediated gene delivery for the treatment of lower urinary tract pain.

10. kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system.