Literature DB >> 25628960

Regulation of T cell receptor complex-mediated signaling by ubiquitin and ubiquitin-like modifications.

Samantha F Friend1, Francina Deason-Towne2, Lisa K Peterson1, Allison J Berger3, Leonard L Dragone4.   

Abstract

Post-translational protein modifications are a dynamic method of regulating protein function in response to environmental signals. As with any cellular process, T cell receptor (TCR) complex-mediated signaling is highly regulated, since the strength and duration of TCR-generated signals governs T cell development and activation. While regulation of TCR complex-mediated signaling by phosphorylation has been well studied, regulation by ubiquitin and ubiquitin-like modifiers is still an emerging area of investigation. This review will examine how ubiquitin, E3 ubiquitin ligases, and other ubiquitin-like modifications such as SUMO and NEDD8 regulate TCR complex-mediated signaling.

Entities:  

Keywords:  MLN4924; NEDD8; SLAP; SUMO; T cell; c-Cbl; ubiquitin

Year:  2014        PMID： 25628960      PMCID： PMC4299764     

Source DB:  PubMed          Journal:  Am J Clin Exp Immunol


  115 in total

1.  Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8.

Authors:  Helen Walden; Michael S Podgorski; Brenda A Schulman
Journal:  Nature       Date:  2003-03-20       Impact factor: 49.962

2.  Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.

Authors:  Bin Liu; Ying Zheng; Tong-Dan Wang; Han-Zhang Xu; Li Xia; Jian Zhang; Ying-Li Wu; Guo-Qiang Chen; Li-Shun Wang
Journal:  J Proteome Res       Date:  2012-02-10       Impact factor: 4.466

Review 3.  SLAP, a regulator of immunoreceptor ubiquitination, signaling, and trafficking.

Authors:  Leonard L Dragone; Laura A Shaw; Margaret D Myers; Arthur Weiss
Journal:  Immunol Rev       Date:  2009-11       Impact factor: 12.988

4.  The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice.

Authors:  W L Perry; C M Hustad; D A Swing; T N O'Sullivan; N A Jenkins; N G Copeland
Journal:  Nat Genet       Date:  1998-02       Impact factor: 38.330

5.  The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2.

Authors:  T Kamura; M N Conrad; Q Yan; R C Conaway; J W Conaway
Journal:  Genes Dev       Date:  1999-11-15       Impact factor: 11.361

Review 6.  Novel substrates and functions for the ubiquitin-like molecule NEDD8.

Authors:  Dimitris P Xirodimas
Journal:  Biochem Soc Trans       Date:  2008-10       Impact factor: 5.407

7.  An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer.

Authors:  Teresa A Soucy; Peter G Smith; Michael A Milhollen; Allison J Berger; James M Gavin; Sharmila Adhikari; James E Brownell; Kristine E Burke; David P Cardin; Stephen Critchley; Courtney A Cullis; Amanda Doucette; James J Garnsey; Jeffrey L Gaulin; Rachel E Gershman; Anna R Lublinsky; Alice McDonald; Hirotake Mizutani; Usha Narayanan; Edward J Olhava; Stephane Peluso; Mansoureh Rezaei; Michael D Sintchak; Tina Talreja; Michael P Thomas; Tary Traore; Stepan Vyskocil; Gabriel S Weatherhead; Jie Yu; Julie Zhang; Lawrence R Dick; Christopher F Claiborne; Mark Rolfe; Joseph B Bolen; Steven P Langston
Journal:  Nature       Date:  2009-04-09       Impact factor: 49.962

8.  Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAIL expression.

Authors:  Jack T Lin; Neil B Lineberry; Michael G Kattah; Leon L Su; Paul J Utz; C Garrison Fathman; Linda Wu
Journal:  J Immunol       Date:  2009-05-15       Impact factor: 5.422

Review 9.  Functional characterization of SAG/RBX2/ROC2/RNF7, an antioxidant protein and an E3 ubiquitin ligase.

Authors:  Yi Sun; Hua Li
Journal:  Protein Cell       Date:  2012-11-08       Impact factor: 14.870

10.  TRAF6 is essential for maintenance of regulatory T cells that suppress Th2 type autoimmunity.

Authors:  Go Muto; Hitoshi Kotani; Taisuke Kondo; Rimpei Morita; Sanae Tsuruta; Takashi Kobayashi; Hervé Luche; Hans Joerg Fehling; Matthew Walsh; Yongwon Choi; Akihiko Yoshimura
Journal:  PLoS One       Date:  2013-09-13       Impact factor: 3.240
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  8 in total

Review 1.  Ubiquitin Ligases and Deubiquitinating Enzymes in CD4+ T Cell Effector Fate Choice and Function.

Authors:  Awo A K Layman; Paula M Oliver
Journal:  J Immunol       Date:  2016-05-15       Impact factor: 5.422

Review 2.  USP15: a review of its implication in immune and inflammatory processes and tumor progression.

Authors:  Anna Georges; Philippe Gros; Nassima Fodil
Journal:  Genes Immun       Date:  2021-04-06       Impact factor: 2.676

Review 3.  Ubiquitination in melanoma pathogenesis and treatment.

Authors:  Jinyuan Ma; Weinan Guo; Chunying Li
Journal:  Cancer Med       Date:  2017-05-23       Impact factor: 4.452

4.  Pan-Cancer Analysis Reveals the Functional Importance of Protein Lysine Modification in Cancer Development.

Authors:  Li Chen; Yanyan Miao; Mengni Liu; Yanru Zeng; Zijun Gao; Di Peng; Bosu Hu; Xu Li; Yueyuan Zheng; Yu Xue; Zhixiang Zuo; Yubin Xie; Jian Ren
Journal:  Front Genet       Date:  2018-07-17       Impact factor: 4.599

Review 5.  Ubiquitylation as a Rheostat for TCR Signaling: From Targeted Approaches Toward Global Profiling.

Authors:  Claire E O'Leary; Emma L Lewis; Paula M Oliver
Journal:  Front Immunol       Date:  2015-12-16       Impact factor: 7.561

6.  Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA-induced differentiation of leukemic cells.

Authors:  Nina Orfali; Deborah Shan-Krauer; Tracey R O'Donovan; Nigel P Mongan; Lorraine J Gudas; Mary R Cahill; Mario P Tschan; Sharon L McKenna
Journal:  Mol Oncol       Date:  2020-05-01       Impact factor: 6.603

7.  CD4+ T Cell Defects in a Mulibrey Patient With Specific TRIM37 Mutations.

Authors:  Sara Bruzzaniti; Emilia Cirillo; Rosaria Prencipe; Giuliana Giardino; Maria Teresa Lepore; Federica Garziano; Francesco Perna; Claudio Procaccini; Luigi Mascolo; Cristina Pagano; Valentina Fattorusso; Enza Mozzillo; Maurizio Bifulco; Giuseppe Matarese; Adriana Franzese; Claudio Pignata; Mario Galgani
Journal:  Front Immunol       Date:  2020-09-18       Impact factor: 7.561

8.  Phosphoproteomics Reveals Regulatory T Cell-Mediated DEF6 Dephosphorylation That Affects Cytokine Expression in Human Conventional T Cells.

Authors:  Rubin N Joshi; Nadine A Binai; Francesco Marabita; Zhenhua Sui; Amnon Altman; Albert J R Heck; Jesper Tegnér; Angelika Schmidt
Journal:  Front Immunol       Date:  2017-09-25       Impact factor: 7.561
  8 in total

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