Literature DB >> 8392754

Subunit identification and reconstitution of the N-type Ca2+ channel complex purified from brain.

D R Witcher1, M De Waard, J Sakamoto, C Franzini-Armstrong, M Pragnell, S D Kahl, K P Campbell.   

Abstract

Calcium channels play an important role in regulating various neuronal processes, including synaptic transmission and cellular plasticity. The N-type calcium channels, which are sensitive to omega-conotoxin, are involved in the control of transmitter release from neurons. A functional N-type calcium channel complex was purified from rabbit brain. The channel consists of a 230-kilodalton subunit (alpha 1B) that is tightly associated with a 160-kilodalton subunit (alpha 2 delta), a 57-kilodalton subunit (beta 3), and a 95-kilodalton glycoprotein subunit. The complex formed a functional calcium channel with the same pharmacological properties and conductance as those of the native omega-conotoxin-sensitive calcium channel in neurons.

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Year:  1993        PMID： 8392754     DOI： 10.1126/science.8392754

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  57 in total

1.  Biphasic, opposing modulation of cloned neuronal alpha1E Ca channels by distinct signaling pathways coupled to M2 muscarinic acetylcholine receptors.

Authors:  U Meza; R Bannister; K Melliti; B Adams
Journal:  J Neurosci       Date:  1999-08-15       Impact factor: 6.167

Review 2.  Interactions between proteins implicated in exocytosis and voltage-gated calcium channels.

Authors:  M Seagar; C Lévêque; N Charvin; B Marquèze; N Martin-Moutot; J A Boudier; J L Boudier; Y Shoji-Kasai; K Sato; M Takahashi
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1999-02-28       Impact factor: 6.237

Review 3.  Regulation of ion channel expression in neural cells by hormones and growth factors.

Authors:  L J Chew; V Gallo
Journal:  Mol Neurobiol       Date:  1998-12       Impact factor: 5.590

4.  Evidence for two concentration-dependent processes for beta-subunit effects on alpha1B calcium channels.

Authors:  C Cantí; A Davies; N S Berrow; A J Butcher; K M Page; A C Dolphin
Journal:  Biophys J       Date:  2001-09       Impact factor: 4.033

5.  Suppression of inflammatory and neuropathic pain symptoms in mice lacking the N-type Ca2+ channel.

Authors:  H Saegusa; T Kurihara; S Zong; A Kazuno ; Y Matsuda; T Nonaka; W Han; H Toriyama; T Tanabe
Journal:  EMBO J       Date:  2001-05-15       Impact factor: 11.598

6.  Auxiliary subunits operate as a molecular switch in determining gating behaviour of the unitary N-type Ca2+ channel current in Xenopus oocytes.

Authors:  M Wakamori; G Mikala; Y Mori
Journal:  J Physiol       Date:  1999-06-15       Impact factor: 5.182

7.  Glycerotoxin from Glycera convoluta stimulates neurosecretion by up-regulating N-type Ca2+ channel activity.

Authors:  Frédéric A Meunier; Zhong-Ping Feng; Jordi Molgó; Gerald W Zamponi; Giampietro Schiavo
Journal:  EMBO J       Date:  2002-12-16       Impact factor: 11.598

Review 8.  Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.

Authors:  Anne Marie R Yunker
Journal:  J Bioenerg Biomembr       Date:  2003-12       Impact factor: 2.945

Review 9.  Beta subunits of voltage-gated calcium channels.

Authors:  Annette C Dolphin
Journal:  J Bioenerg Biomembr       Date:  2003-12       Impact factor: 2.945

Review 10.  Trafficking and stability of voltage-gated calcium channels.

Authors:  Brett A Simms; Gerald W Zamponi
Journal:  Cell Mol Life Sci       Date:  2011-10-02       Impact factor: 9.261
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