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Literature DB >> 15000522

Beta subunits of voltage-gated calcium channels.

Abstract

Calcium channel beta subunits have marked effects on the trafficking and on several of the biophysical properties of all high voltage activated calcium channels. In this article I shall review information on the different genes, on the structure of the beta subunits, and on their differential expression and post-translational modification. Their role in trafficking and assembly of the calcium channel heteromultimer will be described, and I will then review their effects on voltage-dependent and kinetic properties, stressing the differences between palmitoylated beta2a and the other beta subunits. Evidence for effects on calcium channel pharmacology will also be examined. I shall discuss the hypothesis that beta subunits can bind reversibly to calcium channels, and examine their role in the G protein modulation of calcium channels. Finally, I shall describe the consequences of knock-out of different beta subunit genes, and describe evidence for the involvement of beta subunits in disease.

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Year: 2003 PMID： 15000522 DOI： 10.1023/b:jobb.0000008026.37790.5a

Source DB: PubMed Journal: J Bioenerg Biomembr ISSN： 0145-479X Impact factor: 2.945

168 in total

1. Molecular basis for K(ATP) assembly: transmembrane interactions mediate association of a K+ channel with an ABC transporter.

Authors: B Schwappach; N Zerangue; Y N Jan; L Y Jan
Journal: Neuron Date: 2000-04 Impact factor: 17.173

2. Voltage and calcium use the same molecular determinants to inactivate calcium channels.

Authors: T Cens; S Restituito; S Galas; P Charnet
Journal: J Biol Chem Date: 1999-02-26 Impact factor: 5.157

3. The interaction between the I-II loop and the III-IV loop of Cav2.1 contributes to voltage-dependent inactivation in a beta -dependent manner.

Authors: Sandrine Geib; Guillaume Sandoz; Veronique Cornet; Kamel Mabrouk; Odile Fund-Saunier; Delphine Bichet; Michel Villaz; Toshinori Hoshi; Jean-Marc Sabatier; Michel De Waard
Journal: J Biol Chem Date: 2002-01-14 Impact factor: 5.157

Review 4. Post-translational modifications of beta subunits of voltage-dependent calcium channels.

Authors: A J Chien; M M Hosey
Journal: J Bioenerg Biomembr Date: 1998-08 Impact factor: 2.945

5. A Xenopus oocyte beta subunit: evidence for a role in the assembly/expression of voltage-gated calcium channels that is separate from its role as a regulatory subunit.

Authors: E Tareilus; M Roux; N Qin; R Olcese; J Zhou; E Stefani; L Birnbaumer
Journal: Proc Natl Acad Sci U S A Date: 1997-03-04 Impact factor: 11.205

6. IGF-1 modulates N and L calcium channels in a PI 3-kinase-dependent manner.

Authors: L A Blair; J Marshall
Journal: Neuron Date: 1997-08 Impact factor: 17.173

7. Potentiation by the beta subunit of the ratio of the ionic current to the charge movement in the cardiac calcium channel.

Authors: A Neely; X Wei; R Olcese; L Birnbaumer; E Stefani
Journal: Science Date: 1993-10-22 Impact factor: 47.728

8. Pain perception in mice lacking the beta3 subunit of voltage-activated calcium channels.

Authors: Manabu Murakami; Bernd Fleischmann; Carmen De Felipe; Marc Freichel; Claudia Trost; Andreas Ludwig; Ulrich Wissenbach; Herbert Schwegler; Franz Hofmann; Jürgen Hescheler; Veit Flockerzi; Adolfo Cavalié
Journal: J Biol Chem Date: 2002-08-02 Impact factor: 5.157

9. The involvement of multiple calcium channel sub-types in glutamate release from cerebellar granule cells and its modulation by GABAB receptor activation.

Authors: E Huston; G P Cullen; J R Burley; A C Dolphin
Journal: Neuroscience Date: 1995-09 Impact factor: 3.590

10. Mechanism of auxiliary subunit modulation of neuronal alpha1E calcium channels.

Authors: L P Jones; S K Wei; D T Yue
Journal: J Gen Physiol Date: 1998-08 Impact factor: 4.086

151 in total

1. Rem GTPase interacts with the proximal CaV1.2 C-terminus and modulates calcium-dependent channel inactivation.

Authors: Chunyan Pang; Shawn M Crump; Ling Jin; Robert N Correll; Brian S Finlin; Jonathan Satin; Douglas A Andres
Journal: Channels (Austin) Date: 2010-05-01 Impact factor: 2.581

2. Structure of a complex between a voltage-gated calcium channel beta-subunit and an alpha-subunit domain.

Authors: Filip Van Petegem; Kimberly A Clark; Franck C Chatelain; Daniel L Minor
Journal: Nature Date: 2004-05-12 Impact factor: 49.962

Review 3. Calcium channels: unanswered questions.

Authors: Stephen W Jones
Journal: J Bioenerg Biomembr Date: 2003-12 Impact factor: 2.945

4. Oligomerization of Cavbeta subunits is an essential correlate of Ca2+ channel activity.

Authors: Qi Zong Lao; Evgeny Kobrinsky; Zhuo Liu; Nikolai M Soldatov
Journal: FASEB J Date: 2010-08-23 Impact factor: 5.191

5. Direct inhibition of P/Q-type voltage-gated Ca2+ channels by Gem does not require a direct Gem/Cavbeta interaction.

Authors: Mingming Fan; Zafir Buraei; Huai-Rong Luo; Rose Levenson-Palmer; Jian Yang
Journal: Proc Natl Acad Sci U S A Date: 2010-08-02 Impact factor: 11.205

6. Rem-induced inhibition of Ca2+ channels--a three-pronged assault.

Authors: Bernhard E Flucher
Journal: J Physiol Date: 2010-06-01 Impact factor: 5.182

7. Requirements for synaptically evoked plateau potentials in relay cells of the dorsal lateral geniculate nucleus of the mouse.

Authors: Emily K Dilger; Hee-Sup Shin; William Guido
Journal: J Physiol Date: 2010-12-20 Impact factor: 5.182