Literature DB >> 8392224

An NAD derivative produced during transfer RNA splicing: ADP-ribose 1"-2" cyclic phosphate.

G M Culver1, S M McCraith, M Zillmann, R Kierzek, N Michaud, R D LaReau, D H Turner, E M Phizicky.   

Abstract

Transfer RNA (tRNA) splicing is essential in Saccharomyces cerevisiae as well as in humans, and many of its features are the same in both. In yeast, the final step of this process is removal of the 2' phosphate generated at the splice junction during ligation. A nicotinamide adenine dinucleotide (NAD)-dependent phosphotransferase catalyzes removal of the 2' phosphate and produces a small molecule. It is shown here that this small molecule is an NAD derivative: adenosine diphosphate (ADP)-ribose 1"-2" cyclic phosphate. Evidence is also presented that this molecule is produced in Xenopus laevis oocytes as a result of dephosphorylation of ligated tRNA.

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Year:  1993        PMID： 8392224     DOI： 10.1126/science.8392224

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  41 in total

1.  Characterization of the Saccharomyces cerevisiae cyclic nucleotide phosphodiesterase involved in the metabolism of ADP-ribose 1",2"-cyclic phosphate.

Authors:  F Nasr; W Filipowicz
Journal:  Nucleic Acids Res       Date:  2000-04-15       Impact factor: 16.971

2.  Structure and mechanism of activity of the cyclic phosphodiesterase of Appr>p, a product of the tRNA splicing reaction.

Authors:  A Hofmann; A Zdanov; P Genschik; S Ruvinov; W Filipowicz; A Wlodawer
Journal:  EMBO J       Date:  2000-11-15       Impact factor: 11.598

3.  Portability and fidelity of RNA-repair systems.

Authors:  Beate Schwer; Rana Sawaya; C Kiong Ho; Stewart Shuman
Journal:  Proc Natl Acad Sci U S A       Date:  2004-02-18       Impact factor: 11.205

Review 4.  tRNA biology charges to the front.

Authors:  Eric M Phizicky; Anita K Hopper
Journal:  Genes Dev       Date:  2010-09-01       Impact factor: 11.361

5.  The macro domain is an ADP-ribose binding module.

Authors:  Georgios I Karras; Georg Kustatscher; Heeran R Buhecha; Mark D Allen; Céline Pugieux; Fiona Sait; Mark Bycroft; Andreas G Ladurner
Journal:  EMBO J       Date:  2005-05-19       Impact factor: 11.598

6.  Analysis of 2'-phosphotransferase (Tpt1p) from Saccharomyces cerevisiae: evidence for a conserved two-step reaction mechanism.

Authors:  Michelle A Steiger; Jane E Jackman; Eric M Phizicky
Journal:  RNA       Date:  2005-01       Impact factor: 4.942

7.  Structure-function analysis of the yeast NAD+-dependent tRNA 2'-phosphotransferase Tpt1.

Authors:  Rana Sawaya; Beate Schwer; Stewart Shuman
Journal:  RNA       Date:  2005-01       Impact factor: 4.942

Review 8.  Have tRNA, will travel.

Authors:  Eric M Phizicky
Journal:  Proc Natl Acad Sci U S A       Date:  2005-08-01       Impact factor: 11.205

9.  A functional homolog of a yeast tRNA splicing enzyme is conserved in higher eukaryotes and in Escherichia coli.

Authors:  S L Spinelli; H S Malik; S A Consaul; E M Phizicky
Journal:  Proc Natl Acad Sci U S A       Date:  1998-11-24       Impact factor: 11.205

10.  TPD1 of Saccharomyces cerevisiae encodes a protein phosphatase 2C-like activity implicated in tRNA splicing and cell separation.

Authors:  M K Robinson; W H van Zyl; E M Phizicky; J R Broach
Journal:  Mol Cell Biol       Date:  1994-06       Impact factor: 4.272
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