Literature DB >> 2879635

The transforming growth factor-beta system, a complex pattern of cross-reactive ligands and receptors.

S Cheifetz, J A Weatherbee, M L Tsang, J K Anderson, J E Mole, R Lucas, J Massagué.   

Abstract

A new homodimer form of transforming growth factor-beta (TGF-beta), TGF-beta 2, has been identified in porcine blood platelets. TGF-beta 2 is homologous to ordinary TGF-beta (TGF-beta 1), which is also present in platelets. TGF-beta 1.2, a heterodimer containing one TGF-beta 1 chain and one TGF-beta 2 chain, has also been isolated. TGF-beta 1 and TGF-beta 2 interact differently with a family of receptors in target cells. A 280 kd receptor displays high affinity for both TGF-beta 1 and TGF-beta 2. Occupancy of this receptor by TGF-beta 1 or TGF-beta 2 correlates with the ability of these TGF-beta s to inhibit cell proliferation. In contrast, 65 kd and 85 kd receptors have high affinity for TGF-beta 1 but lower affinity for TGF-beta 2. The existence of distinct forms of TGF-beta that interact differently with a family of TGF-beta receptors could provide flexibility to the regulation of tissue growth and differentiation by the TGF-beta system.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 2879635     DOI： 10.1016/0092-8674(87)90192-9

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  125 in total

1.  Transforming growth factor-ßs as modulators of pericellular proteolytic events.

Authors:  J Keski-Oja; J Lohi; M Laiho
Journal:  Cytotechnology       Date:  1989-12       Impact factor: 2.058

Review 2.  Polypeptide growth factors and the kidney: a developmental perspective.

Authors:  E D Avner
Journal:  Pediatr Nephrol       Date:  1990-07       Impact factor: 3.714

Review 3.  TGF-beta: problems and prospects.

Authors:  M B Sporn; A B Roberts
Journal:  Cell Regul       Date:  1990-11

Review 4.  Growth inhibitors: molecular diversity and roles in cell proliferation.

Authors:  K Miyazaki; T Horio
Journal:  In Vitro Cell Dev Biol       Date:  1989-10

5.  Identification of a structural domain that distinguishes the actions of the type 1 and 2 isoforms of transforming growth factor beta on endothelial cells.

Authors:  S W Qian; J K Burmester; J R Merwin; J A Madri; M B Sporn; A B Roberts
Journal:  Proc Natl Acad Sci U S A       Date:  1992-07-15       Impact factor: 11.205

6.  Evidence for the involvement of protein kinase activity in transforming growth factor-beta signal transduction.

Authors:  M Ohtsuki; J Massagué
Journal:  Mol Cell Biol       Date:  1992-01       Impact factor: 4.272

7.  Correlation of fibrosis and transforming growth factor-beta type 2 levels in the eye.

Authors:  T B Connor; A B Roberts; M B Sporn; D Danielpour; L L Dart; R G Michels; S de Bustros; C Enger; H Kato; M Lansing
Journal:  J Clin Invest       Date:  1989-05       Impact factor: 14.808

8.  Characterization of a human hepatoma cell line with acquired resistance to growth inhibition by transforming growth factor beta 1 (TGF-beta 1).

Authors:  K Hasegawa; Z Wang; M Inagaki; B I Carr
Journal:  In Vitro Cell Dev Biol Anim       Date:  1995-01       Impact factor: 2.416

9.  Vascular cells respond differentially to transforming growth factors beta 1 and beta 2 in vitro.

Authors:  J R Merwin; W Newman; L D Beall; A Tucker; J Madri
Journal:  Am J Pathol       Date:  1991-01       Impact factor: 4.307

Review 10.  Bioinformatic approaches to augment study of epithelial-to-mesenchymal transition in lung cancer.

Authors:  Tim N Beck; Adaeze J Chikwem; Nehal R Solanki; Erica A Golemis
Journal:  Physiol Genomics       Date:  2014-08-05       Impact factor: 3.107
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.