Literature DB >> 8388517

The herpes simplex virus type 1 reactivation function lies outside the latency-associated transcript open reading frame ORF-2.

M J Farrell1, J M Hill, T P Margolis, J G Stevens, E K Wagner, L T Feldman.   

Abstract

The latency-associated transcription unit has been shown to be important for in vivo reactivation of herpes simplex virus from the latent state. A recombinant virus was constructed to alter the largest open reading frame in this region. This virus had a wild-type reactivation phenotype, suggesting that herpes simplex virus does not require a protein function from this reading frame for efficient reactivation from latency.

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Year:  1993        PMID： 8388517      PMCID： PMC237719     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  26 in total

1.  Sequence of the latency-related gene of herpes simplex virus type 1.

Authors:  S L Wechsler; A B Nesburn; J Zwaagstra; H Ghiasi
Journal:  Virology       Date:  1989-01       Impact factor: 3.616

2.  Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency.

Authors:  D A Leib; D M Coen; C L Bogard; K A Hicks; D R Yager; D M Knipe; K L Tyler; P A Schaffer
Journal:  J Virol       Date:  1989-02       Impact factor: 5.103

3.  A herpes simplex virus transcript abundant in latently infected neurons is dispensable for establishment of the latent state.

Authors:  R T Javier; J G Stevens; V B Dissette; E K Wagner
Journal:  Virology       Date:  1988-09       Impact factor: 3.616

4.  Physical characterization of the herpes simplex virus latency-associated transcript in neurons.

Authors:  E K Wagner; G Devi-Rao; L T Feldman; A T Dobson; Y F Zhang; W M Flanagan; J G Stevens
Journal:  J Virol       Date:  1988-04       Impact factor: 5.103

5.  Fine mapping of the major latency-related RNA of herpes simplex virus type 1 in humans.

Authors:  S L Wechsler; A B Nesburn; R Watson; S Slanina; H Ghiasi
Journal:  J Gen Virol       Date:  1988-12       Impact factor: 3.891

6.  The herpes simplex virus latency-associated transcript is spliced during the latent phase of infection.

Authors:  E K Wagner; W M Flanagan; G Devi-Rao; Y F Zhang; J M Hill; K P Anderson; J G Stevens
Journal:  J Virol       Date:  1988-12       Impact factor: 5.103

7.  Fine mapping of the latency-related gene of herpes simplex virus type 1: alternative splicing produces distinct latency-related RNAs containing open reading frames.

Authors:  S L Wechsler; A B Nesburn; R Watson; S M Slanina; H Ghiasi
Journal:  J Virol       Date:  1988-11       Impact factor: 5.103

8.  A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency.

Authors:  D A Leib; C L Bogard; M Kosz-Vnenchak; K A Hicks; D M Coen; D M Knipe; P A Schaffer
Journal:  J Virol       Date:  1989-07       Impact factor: 5.103

9.  RNA complementary to herpes simplex virus type 1 ICP0 gene demonstrated in neurons of human trigeminal ganglia.

Authors:  Y J Gordon; B Johnson; E Romanowski; T Araullo-Cruz
Journal:  J Virol       Date:  1988-05       Impact factor: 5.103

10.  Herpes simplex virus type 1 latency-associated transcripts are evidently not essential for latent infection.

Authors:  I Steiner; J G Spivack; R P Lirette; S M Brown; A R MacLean; J H Subak-Sharpe; N W Fraser
Journal:  EMBO J       Date:  1989-02       Impact factor: 11.598
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  17 in total

1.  A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.

Authors:  D C Bloom; J M Hill; G Devi-Rao; E K Wagner; L T Feldman; J G Stevens
Journal:  J Virol       Date:  1996-04       Impact factor: 5.103

Review 2.  Experimental investigation of herpes simplex virus latency.

Authors:  E K Wagner; D C Bloom
Journal:  Clin Microbiol Rev       Date:  1997-07       Impact factor: 26.132

3.  A protein encoded by the herpes simplex virus (HSV) type 1 2-kilobase latency-associated transcript is phosphorylated, localized to the nucleus, and overcomes the repression of expression from exogenous promoters when inserted into the quiescent HSV genome.

Authors:  S K Thomas; C E Lilley; D S Latchman; R S Coffin
Journal:  J Virol       Date:  2002-04       Impact factor: 5.103

4.  A novel explanation for the existence of open reading frames on latency-associated transcripts of alphaherpesviruses.

Authors:  Z Boldogköi; J Murvai
Journal:  Virus Genes       Date:  1994-09       Impact factor: 2.332

5.  Analysis of a herpes simplex virus type 1 LAT mutant with a deletion between the putative promoter and the 5' end of the 2.0-kilobase transcript.

Authors:  J Maggioncalda; A Mehta; N W Fraser; T M Block
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

6.  The abundant latency-associated transcripts of herpes simplex virus type 1 are bound to polyribosomes in cultured neuronal cells and during latent infection in mouse trigeminal ganglia.

Authors:  D Goldenberg; N Mador; M J Ball; A Panet; I Steiner
Journal:  J Virol       Date:  1997-04       Impact factor: 5.103

7.  Two open reading frames (ORF1 and ORF2) within the 2.0-kilobase latency-associated transcript of herpes simplex virus type 1 are not essential for reactivation from latency.

Authors:  M U Fareed; J G Spivack
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

8.  Herpes simplex virus type 1 DNA replication and gene expression during explant-induced reactivation of latently infected murine sensory ganglia.

Authors:  G B Devi-Rao; D C Bloom; J G Stevens; E K Wagner
Journal:  J Virol       Date:  1994-03       Impact factor: 5.103

9.  Molecular analysis of herpes simplex virus type 1 during epinephrine-induced reactivation of latently infected rabbits in vivo.

Authors:  D C Bloom; G B Devi-Rao; J M Hill; J G Stevens; E K Wagner
Journal:  J Virol       Date:  1994-03       Impact factor: 5.103

10.  Quantitation of herpes simplex virus type 1 DNA and latency-associated transcripts in rabbit trigeminal ganglia demonstrates a stable reservoir of viral nucleic acids during latency.

Authors:  J M Hill; B M Gebhardt; R Wen; A M Bouterie; H W Thompson; R J O'Callaghan; W P Halford; H E Kaufman
Journal:  J Virol       Date:  1996-05       Impact factor: 5.103
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