Literature DB >> 2535901

Sequence of the latency-related gene of herpes simplex virus type 1.

S L Wechsler1, A B Nesburn, J Zwaagstra, H Ghiasi.   

Abstract

During herpes simplex virus type 1 latency in neurons, RNA is transcribed from one small region of the viral genome. This latency-related RNA (LR RNA) is antisense to the mRNA of the immediate early gene ICPO, partially overlaps the ICPO mRNA, and is suspected of playing some role in helping maintain latency. We report here the sequence of the latency-related gene (LR gene) and its flanking sequences from strain F, and compare it to the available partial sequences of this region from strains 17 syn+ and KOS. Two potential open reading frames (ORFs) were common to all three sequences. Sequence analysis suggested the possibility of promoters in two different regions of the LR gene.

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Year:  1989        PMID： 2535901     DOI： 10.1016/0042-6822(89)90416-9

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  46 in total

1.  Herpes simplex virus latent RNA (LAT) is not required for latent infection in the mouse.

Authors:  D Y Ho; E S Mocarski
Journal:  Proc Natl Acad Sci U S A       Date:  1989-10       Impact factor: 11.205

2.  Localization of cis-acting sequence requirements in the promoter of the latency-associated transcript of herpes simplex virus type 1 required for cell-type-specific activity.

Authors:  A H Batchelor; P O'Hare
Journal:  J Virol       Date:  1992-06       Impact factor: 5.103

3.  Herpes simplex virus latency-associated transcript is a stable intron.

Authors:  M J Farrell; A T Dobson; L T Feldman
Journal:  Proc Natl Acad Sci U S A       Date:  1991-02-01       Impact factor: 11.205

4.  An antigen encoded by the latency-associated transcript in neuronal cell cultures latently infected with herpes simplex virus type 1.

Authors:  C Doerig; L I Pizer; C L Wilcox
Journal:  J Virol       Date:  1991-05       Impact factor: 5.103

5.  Detection of latent thymidine kinase-deficient herpes simplex virus in trigeminal ganglia of mice using the polymerase chain reaction.

Authors:  A Friedrich; J P Kleim; K E Schneweis
Journal:  Arch Virol       Date:  1990       Impact factor: 2.574

6.  Activity of herpes simplex virus type 1 latency-associated transcript (LAT) promoter in neuron-derived cells: evidence for neuron specificity and for a large LAT transcript.

Authors:  J C Zwaagstra; H Ghiasi; S M Slanina; A B Nesburn; S C Wheatley; K Lillycrop; J Wood; D S Latchman; K Patel; S L Wechsler
Journal:  J Virol       Date:  1990-10       Impact factor: 5.103

7.  Immunological diagnosis in viral infections of the central nervous system: course of antibody titres against homo- and heterologous viruses.

Authors:  R H Dennin; E Herb
Journal:  Med Microbiol Immunol       Date:  1989       Impact factor: 3.402

8.  Two open reading frames (ORF1 and ORF2) within the 2.0-kilobase latency-associated transcript of herpes simplex virus type 1 are not essential for reactivation from latency.

Authors:  M U Fareed; J G Spivack
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

9.  The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latency.

Authors:  G C Perng; E C Dunkel; P A Geary; S M Slanina; H Ghiasi; R Kaiwar; A B Nesburn; S L Wechsler
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

10.  Involvement of a high-mobility-group protein in the transcriptional activity of herpes simplex virus latency-active promoter 2.

Authors:  S W French; M C Schmidt; J C Glorioso
Journal:  Mol Cell Biol       Date:  1996-10       Impact factor: 4.272
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