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Literature DB >> 8385799

Distinct functions of SR proteins in alternative pre-mRNA splicing.

A M Zahler¹, K M Neugebauer, W S Lane, M B Roth.

Abstract

Alternative splicing of precursor messenger RNAs (pre-mRNAs) is a common mechanism of regulating gene expression. SR proteins are a family of pre-mRNA splicing factors that are structurally related and evolutionarily conserved. Any member of the SR family can complement a splicing-deficient extract that lacks the entire family of SR proteins. Here it is demonstrated that particular SR proteins have distinct functions in alternative pre-mRNA splicing in vitro. In addition, SR proteins are differentially expressed in a variety of tissues. These results suggest a fundamental role for SR proteins in the regulation of alternative splicing.

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Year: 1993 PMID： 8385799 DOI： 10.1126/science.8385799

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

159 in total

1. Identification of a bidirectional splicing enhancer: differential involvement of SR proteins in 5' or 3' splice site activation.

Authors: C F Bourgeois; M Popielarz; G Hildwein; J Stevenin
Journal: Mol Cell Biol Date: 1999-11 Impact factor: 4.272

2. The levels of the bancal product, a Drosophila homologue of vertebrate hnRNP K protein, affect cell proliferation and apoptosis in imaginal disc cells.

Authors: B Charroux; C Angelats; L Fasano; S Kerridge; C Vola
Journal: Mol Cell Biol Date: 1999-11 Impact factor: 4.272

3. Identification and characterization of a novel serine-arginine-rich splicing regulatory protein.

Authors: D C Barnard; J G Patton
Journal: Mol Cell Biol Date: 2000-05 Impact factor: 4.272

4. The splicing factors 9G8 and SRp20 transactivate splicing through different and specific enhancers.

Authors: Y Cavaloc; C F Bourgeois; L Kister; J Stévenin
Journal: RNA Date: 1999-03 Impact factor: 4.942

5. Alternative splicing of U12-dependent introns in vivo responds to purine-rich enhancers.

Authors: R C Dietrich; G C Shukla; J D Fuller; R A Padgett
Journal: RNA Date: 2001-10 Impact factor: 4.942

Review 6. Sorting out the complexity of SR protein functions.

Authors: B R Graveley
Journal: RNA Date: 2000-09 Impact factor: 4.942

7. Overexpression of essential splicing factor ASF/SF2 blocks the temporal shift in adenovirus pre-mRNA splicing and reduces virus progeny formation.

Authors: M Molin; G Akusjärvi
Journal: J Virol Date: 2000-10 Impact factor: 5.103