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Literature DB >> 8383250

Truncation of the carboxy-terminal 28 amino acids of glycoprotein B specified by herpes simplex virus type 1 mutant amb1511-7 causes extensive cell fusion.

A Baghian¹, L Huang, S Newman, S Jayachandra, K G Kousoulas.

Abstract

Three amber mutations were introduced proximal to the syn3 locus of the herpes simplex virus type 1 glycoprotein B (gB) gene specifying gB derivatives lacking the carboxy-terminal 28, 49, or 64 amino acids. A complementation system that utilized gBs expressed in COS cells to complement gB-null virus K delta T was established. The 49- or 64-amino-acid-truncated gBs failed to complement gB-null virus K delta T, while the 28-amino-acid-truncated gB complemented K delta T efficiently. Mutant herpes simplex virus type 1 KOS (amb1511-7) specifying the 28-amino-acid-truncated gB fused Vero cells extensively.

Entities: Chemical Species

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Year: 1993 PMID： 8383250 PMCID： PMC240410

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

24 in total

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45 in total

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Authors: J Rajcáni; M Kúdelová
Journal: Virus Genes Date: 1999 Impact factor: 2.332

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Journal: J Virol Date: 2002-09 Impact factor: 5.103

3. Coexpression of UL20p and gK inhibits cell-cell fusion mediated by herpes simplex virus glycoproteins gD, gH-gL, and wild-type gB or an endocytosis-defective gB mutant and downmodulates their cell surface expression.

Authors: Elisa Avitabile; Giulia Lombardi; Tatiana Gianni; Miriam Capri; Gabriella Campadelli-Fiume
Journal: J Virol Date: 2004-08 Impact factor: 5.103

4. Residues within the C-terminal arm of the herpes simplex virus 1 glycoprotein B ectodomain contribute to its refolding during the fusion step of virus entry.

Authors: Sarah A Connolly; Richard Longnecker
Journal: J Virol Date: 2012-04-04 Impact factor: 5.103

5. Intracellular trafficking and maturation of herpes simplex virus type 1 gB and virus egress require functional biogenesis of multivesicular bodies.

Authors: Arianna Calistri; Paola Sette; Cristiano Salata; Enrico Cancellotti; Cristina Forghieri; Alessandra Comin; Heinrich Göttlinger; Gabriella Campadelli-Fiume; Giorgio Palù; Cristina Parolin
Journal: J Virol Date: 2007-08-08 Impact factor: 5.103

6. Dual split protein-based fusion assay reveals that mutations to herpes simplex virus (HSV) glycoprotein gB alter the kinetics of cell-cell fusion induced by HSV entry glycoproteins.

Authors: Doina Atanasiu; Wan Ting Saw; John R Gallagher; Brian P Hannah; Zene Matsuda; J Charles Whitbeck; Gary H Cohen; Roselyn J Eisenberg
Journal: J Virol Date: 2013-08-14 Impact factor: 5.103