Literature DB >> 8381713

Trisomy 8 as a recurrent clonal abnormality in breast cancer?

J Bullerdiek1, E Leuschner, E Taquia, U Bonk, S Bartnitzke.   

Abstract

The results of cytogenetic investigations on one benign and 15 malignant breast tumors are described. Trisomy 7, 8, 18, and 21 and monosomy X occurred as clonal numerical aberrations, and inv(7)(q21q31) and t(4;12)(q21;p13) occurred as clonal structural aberrations. Only trisomy 8 was a recurrent karyotypic abnormality, however. Thus, we assumed that trisomy 8 as an early genetic change characterizes a subtype of ductal breast carcinomas.

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Year:  1993        PMID： 8381713     DOI： 10.1016/0165-4608(93)90060-y

Source DB:  PubMed          Journal:  Cancer Genet Cytogenet        ISSN： 0165-4608


  5 in total

1.  Fluorescent in situ hybridization assessment of chromosome 8 copy number in breast cancer.

Authors:  A Afify; K I Bland; H F Mark
Journal:  Breast Cancer Res Treat       Date:  1996       Impact factor: 4.872

Review 2.  Review of allelic loss and gain in prostate cancer.

Authors:  G S Bova; W B Isaacs
Journal:  World J Urol       Date:  1996       Impact factor: 4.226

3.  Allelic imbalance of 8p indicates poor survival in gastric cancer.

Authors:  Amy J French; Gina Petroni; Stephen N Thibideau; Mark Smolkin; Eric Bissonette; Franco Roviello; Jeffrey C Harper; Benjamin R Koch; Sarah A Anderson; Scott J Hebbring; Steven M Powell
Journal:  J Mol Diagn       Date:  2004-08       Impact factor: 5.568

4.  A characteristic sequence of trisomies starting with trisomy 7 in benign thyroid tumors.

Authors:  G Belge; B Thode; V Rippe; S Bartnitzke; J Bullerdiek
Journal:  Hum Genet       Date:  1994-08       Impact factor: 4.132

5.  A fibroadenoma with a t(4;12) (q27;q15) affecting the HMGI-C gene, a member of the high mobility group protein gene family.

Authors:  B Staats; U Bonk; S Wanschura; P Hanisch; E F Schoenmakers; W J Van de Ven; S Bartnitzke; J Bullerdiek
Journal:  Breast Cancer Res Treat       Date:  1996       Impact factor: 4.872
  5 in total

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