Literature DB >> 8380599

Experimental implant-related osteomyelitis treated by antibiotic-calcium hydroxyapatite ceramic composites.

F Korkusuz1, A Uchida, Y Shinto, N Araki, K Inoue, K Ono.   

Abstract

The efficacy of locally implanted antibiotic-calcium hydroxyapatite ceramic composites was investigated for the treatment of experimentally produced, implant-related osteomyelitis in rats. High concentrations of antibiotics were detected at the site of infection and bacteria were eradicated without removal of the metal implants. Parenteral antibiotics and surgical debridement, alone or in combination with antibiotic-impregnated acrylic bone cement, all failed to eradicate the infections.

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Year:  1993        PMID： 8380599

Source DB:  PubMed          Journal:  J Bone Joint Surg Br        ISSN： 0301-620X


  9 in total

1.  The bacterial inhibitory ability and in vivo drug release pattern of a new drug delivery system: ciprofloxacine/tricalcium phosphate delivery capsule.

Authors:  Q Zheng; H Wu; J Du; S Li; Y Yan
Journal:  J Tongji Med Univ       Date:  1998

Review 2.  [Bone substitute materials as local drug carriers : Current status of substitutes of various origins].

Authors:  K-D Kühn; C Berberich; H Bösebeck
Journal:  Orthopade       Date:  2018-01       Impact factor: 1.087

3.  An investigation of the chemical synthesis and high-temperature sintering behaviour of calcium hydroxyapatite (HA) and tricalcium phosphate (TCP) bioceramics.

Authors:  A Cüneyt Taş; F Korkusuz; M Timuçin; N Akkaş
Journal:  J Mater Sci Mater Med       Date:  1997-02       Impact factor: 3.896

Review 4.  A systematic review of animal models for Staphylococcus aureus osteomyelitis.

Authors:  W Reizner; J G Hunter; N T O'Malley; R D Southgate; E M Schwarz; S L Kates
Journal:  Eur Cell Mater       Date:  2014-03-25       Impact factor: 3.942

5.  An effective treatment of experimental osteomyelitis using the antimicrobial titanium/silver-containing nHP66 (nano-hydroxyapatite/polyamide-66) nanoscaffold biomaterials.

Authors:  Minpeng Lu; Junyi Liao; Jing Dong; Jun Wu; Hao Qiu; Xin Zhou; Jidong Li; Dianming Jiang; Tong-Chuan He; Zhengxue Quan
Journal:  Sci Rep       Date:  2016-12-16       Impact factor: 4.379

Review 6.  Ceramic Biocomposites as Biodegradable Antibiotic Carriers in the Treatment of Bone Infections.

Authors:  Jamie Ferguson; Michael Diefenbeck; Martin McNally
Journal:  J Bone Jt Infect       Date:  2017-01-01

7.  New Horizons for Hydroxyapatite Supported by DXA Assessment-A Preliminary Study.

Authors:  Jakub Litak; Cezary Grochowski; Andrzej Rysak; Marek Mazurek; Tomasz Blicharski; Piotr Kamieniak; Piotr Wolszczak; Mansur Rahnama-Hezavah; Grzegorz Litak
Journal:  Materials (Basel)       Date:  2022-01-26       Impact factor: 3.623

Review 8.  Animal Models for Postoperative Implant-Related Spinal Infection.

Authors:  Yongjie Wang; Mingxue Che; Zhi Zheng; Jun Liu; Xue Ji; Yang Sun; Jingguo Xin; Weiquan Gong; Shibo Na; Yuanzhe Jin; Shuo Wang; Shaokun Zhang
Journal:  Orthop Surg       Date:  2022-04-25       Impact factor: 2.279

9.  Ceramic composite with gentamicin decreases persistent infection and increases bone formation in a rat model of debrided osteomyelitis.

Authors:  Aleksey Dvorzhinskiy; Giorgio Perino; Robert Chojnowski; Marjolein C H van der Meulen; Mathias P G Bostrom; Xu Yang
Journal:  J Bone Jt Infect       Date:  2021-07-20
  9 in total

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