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Literature DB >> 8380461

Herpes simplex virus type 1 ICP8: helix-destabilizing properties.

Abstract

The major single-stranded DNA-binding protein, ICP8, of herpes simplex virus type 1 (HSV-1) is one of seven virus-encoded polypeptides required for HSV-1 DNA replication. To investigate the role of ICP8 in viral DNA replication, we have examined the interaction of ICP8 with partial DNA duplexes and found that it can displace oligonucleotides annealed to single-stranded M13 DNA. In addition, ICP8 can melt small fragments of fully duplex DNA. Unlike a DNA helicase, ICP8-promoted strand displacement is ATP and Mg2+ independent and exhibits no directionality. It requires saturating amounts of ICP8 and is both efficient and highly cooperative. These properties make ICP8 suitable for a role in DNA replication in which ICP8 destabilizes duplex DNA during origin unwinding and replication fork movement.

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Year: 1993 PMID： 8380461 PMCID： PMC237422

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

34 in total

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32 in total

1. Identification and characterization of the helix-destabilizing activity of rotavirus nonstructural protein NSP2.

Authors: Z F Taraporewala; J T Patton
Journal: J Virol Date: 2001-05 Impact factor: 5.103

2. The 60-residue C-terminal region of the single-stranded DNA binding protein of herpes simplex virus type 1 is required for cooperative DNA binding.

Authors: M Mapelli; M Mühleisen; G Persico; H van Der Zandt; P A Tucker
Journal: J Virol Date: 2000-10 Impact factor: 5.103

3. Multimerization of the adenovirus DNA-binding protein is the driving force for ATP-independent DNA unwinding during strand displacement synthesis.

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Journal: EMBO J Date: 1997-03-17 Impact factor: 11.598

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Authors: Amitabh V Nimonkar; Paul E Boehmer
Journal: Nucleic Acids Res Date: 2003-09-15 Impact factor: 16.971

5. Coordinated leading and lagging strand DNA synthesis by using the herpes simplex virus 1 replication complex and minicircle DNA templates.

Authors: Gudrun Stengel; Robert D Kuchta
Journal: J Virol Date: 2010-11-10 Impact factor: 5.103

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Authors: Seongman Kim; Byung Chul Ahn; Dennis J O'Callaghan; Seong Kee Kim
Journal: Virology Date: 2012-06-20 Impact factor: 3.616

10. The UL8 subunit of the helicase-primase complex of herpes simplex virus promotes DNA annealing and has a high affinity for replication forks.

Authors: Oya Bermek; Sandra K Weller; Jack D Griffith
Journal: J Biol Chem Date: 2017-07-25 Impact factor: 5.157