| Literature DB >> 8374073 |
Abstract
The search for genes in a newly sequenced DNA is a well known problem. Among other factors, the gene-searching process is hampered by a number of ambiguities which may remain unresolved experimentally for a long time. A computer method that is able to predict genes in a DNA sequence containing ambiguities has been developed, based on the non-homogeneous Markov chain technique. The reliability of the method has been tested using a set of sequences generated by a Monte-Carlo procedure and a set of 425 E. coli sequences with ambiguities introduced artificially.Entities:
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Year: 1993 PMID: 8374073 DOI: 10.1016/0303-2647(93)90068-n
Source DB: PubMed Journal: Biosystems ISSN: 0303-2647 Impact factor: 1.973