OBJECTIVE: Seventeen knees in 13 patients with rheumatoid arthritis (RA) were studied with MRI to clarify the dynamics of Gd-DTPA administered intravenously and to determine an optimal imaging time. MATERIALS AND METHODS: Dynamic gradient recalled echo imaging with bolus intravenous injection of Gd-DTPA was performed following unenhanced T1- and T2-weighted SE imaging. Late-phase SE or serial gradient recalled echo images were obtained following dynamic study. RESULTS: There was rapid enhancement of synovium with maximal enhancement ratio of 96-499% (mean 214 +/- 111%) with Tmax ranging from 120 to 660 s (mean 253 s). The synovial enhancement persisted over 80% of the peak enhancement for 6-27 min (average 12 min) with eventual enhancement of joint effusion from the periphery to the center beginning at 6 min to 8 min, 20 s after contrast medium injection. Complete enhancement of joint effusion was noted in four joints at 24-86 min. CONCLUSION: We conclude that enhancement of synovium in patients with RA is a time-dependent phenomenon, and an optimal imaging time would be within 5 min following contrast medium administration.
OBJECTIVE: Seventeen knees in 13 patients with rheumatoid arthritis (RA) were studied with MRI to clarify the dynamics of Gd-DTPA administered intravenously and to determine an optimal imaging time. MATERIALS AND METHODS: Dynamic gradient recalled echo imaging with bolus intravenous injection of Gd-DTPA was performed following unenhanced T1- and T2-weighted SE imaging. Late-phase SE or serial gradient recalled echo images were obtained following dynamic study. RESULTS: There was rapid enhancement of synovium with maximal enhancement ratio of 96-499% (mean 214 +/- 111%) with Tmax ranging from 120 to 660 s (mean 253 s). The synovial enhancement persisted over 80% of the peak enhancement for 6-27 min (average 12 min) with eventual enhancement of joint effusion from the periphery to the center beginning at 6 min to 8 min, 20 s after contrast medium injection. Complete enhancement of joint effusion was noted in four joints at 24-86 min. CONCLUSION: We conclude that enhancement of synovium in patients with RA is a time-dependent phenomenon, and an optimal imaging time would be within 5 min following contrast medium administration.
Authors: Jasper F M M Rieter; Laura Tanturri de Horatio; Charlotte M Nusman; Lil-Sofie Ording Müller; Robert Hemke; Derk F M Avenarius; Marion A J van Rossum; Clara Malattia; Mario Maas; Karen Rosendahl Journal: Pediatr Radiol Date: 2016-07-12
Authors: Anouk M Barendregt; E Charlotte van Gulik; Paul F C Groot; Koert M Dolman; J Merlijn van den Berg; Amara Nassar-Sheikh Rashid; Dieneke Schonenberg-Meinema; Cristina Lavini; Karen Rosendahl; Robert Hemke; Taco W Kuijpers; Mario Maas; Charlotte M Nusman Journal: Pediatr Radiol Date: 2019-02-01