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Literature DB >> 837012

Vascular reactivity of perfused vascular bed in spontaneously hypertensive and normotensive rats.

B K Bhattacharya, N K Dadkar, A N Dohadwalla.

Abstract

1 Hypertensive and normotensive rats of the same age group were isolated from an inbred colony of spontaneously hypertensive rats. 2 The perfused hindquarter and mesenteric artery preparations obtained from hypertensive and normotensive rats exhibited an increased reactivity to noradrenaline (NA) and angiotensin II. 3 Dose-response curves to NA obtained from hypertensive and normotensive rats exhibited a steeper slope and higher maximum than those from control rats. 4 These findings suggest that increased vascular reactivity of blood vessels is independent of the development or maintenance of elevated blood pressure.

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Year: 1977 PMID： 837012 PMCID： PMC1667730 DOI： 10.1111/j.1476-5381.1977.tb07485.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

9 in total

1. Active relfex dilatation in the innervated perfused hind leg of the dog.

Authors: L BECK
Journal: Am J Physiol Date: 1961-07

2. Development of a strain of spontaneously hypertensive rats.

Authors: K OKAMOTO; K AOKI
Journal: Jpn Circ J Date: 1963-03

3. Adaptive structural changes of the vascular walls in hypertension and their relation to the control of the peripheral resistance.

Authors: B FOLKOW; G GRIMBY; O THULESIUS
Journal: Acta Physiol Scand Date: 1958-12-15

2 in total

1. Corticosteroid involvement in the changes in noradrenergic responsiveness of tissues from rats made hypertensive by short-term isolation.

Authors: T Bennett; S M Gardiner
Journal: Br J Pharmacol Date: 1978-09 Impact factor: 8.739

Review 2. Role of the adrenal cortex and sodium in the pathogenesis of human hypertension.

Authors: J Genest; W Nowaczynski; R Boucher; O Kuchel
Journal: Can Med Assoc J Date: 1978-03-04 Impact factor: 8.262

2 in total

Vascular reactivity of perfused vascular bed in spontaneously hypertensive and normotensive rats.

1. Active relfex dilatation in the innervated perfused hind leg of the dog.

2. Development of a strain of spontaneously hypertensive rats.

3. Adaptive structural changes of the vascular walls in hypertension and their relation to the control of the peripheral resistance.

4. Vascular reactivity in spontaneously hypertensive normotensive and hypotensive rats.

5. Vascular reactivity to 5-hydroxytryptamine and hypertension in the rat.

6. Structurally based increase of flow resistance in spontaneously hypertensive rats.

7. Background of increased flow resistance and vascular reactivity in spontaneously hypertensive rats.

8. Vascular reactivity in hypertensive rats after treatment with anti-hypertensive agents.

9. An increased reactivity in hypertensive rats unaffected by prolonged antihypertensive therapy.

1. Corticosteroid involvement in the changes in noradrenergic responsiveness of tissues from rats made hypertensive by short-term isolation.

Review 2. Role of the adrenal cortex and sodium in the pathogenesis of human hypertension.