Literature DB >> 836410

N-(5'-Phosphopyridoxyl)-4-aminobutyric acid: a stabel bisubstrate adduct inhibitor of rat brain 4-aminobutyric acid aminotransferase.

G Tunnicliff, T T Ngo, A Barbeau.   

Abstract

N-(5'-Phosphophopyridoxyl)-4-aminobutyric acid, a stable adduct of pyridoxal phosphate and 4-aminobutyrate acid, has been shown to be a potent inhibitor of rat brain 4-aminobutyric acid aminotransferase (GABA-T) with a K1 of 1.4 muM.

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Year:  1977        PMID： 836410     DOI： 10.1007/BF01936728

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  8 in total

1.  Purification and studies on some properties of the 4-aminobutyrate : 2-oxoglutarate transaminase from rat brain.

Authors:  M Maître; L Ciesielski; C Cash; P Mandel
Journal:  Eur J Biochem       Date:  1975-03-03

Review 2.  Epilepsy and gamma-aminobutyric acid-mediated inhibition.

Authors:  B S Meldrum
Journal:  Int Rev Neurobiol       Date:  1975       Impact factor: 3.230

3.  The synthesis and properties of phosphopyridoxyl amino acids.

Authors:  E S Severin; N N Gulyaev; E N Khurs; R M Khomutov
Journal:  Biochem Biophys Res Commun       Date:  1969-05-08       Impact factor: 3.575

4.  Differences in biochemical properties of gamma-aminobutyric acid aminotransferase from synaptosome-enriched and cytoplasmic mitochondria-enriched subcellular fractions of mouse brain.

Authors:  N T Buu; N M van Gelder
Journal:  Can J Physiol Pharmacol       Date:  1974-06       Impact factor: 2.273

5.  Gamma-aminobutyric acid and nervous system function--a perspective.

Authors:  E Roberts
Journal:  Biochem Pharmacol       Date:  1974-10-01       Impact factor: 5.858

6.  Stable multisubstrate adducts as enzyme inhibitors. Potent inhibition of ornithine decarboxylase by N-(5'-phosphopyridoxyl)-ornithine.

Authors:  J S Heller; E S Canellakis; D L Bussolotti; J K Coward
Journal:  Biochim Biophys Acta       Date:  1975-09-22

Review 7.  The role of gamma-aminobutyric acid in the mechanism of seizures.

Authors:  J D Wood
Journal:  Prog Neurobiol       Date:  1975       Impact factor: 11.685

8.  N-(5'-phosphopyridoxyl)glutamic acid and N-(5'-phosphopyridoxyl)-2-oxopyrrolidine-5-carboxylic acid and their action on the apoenzyme of aspartate aminotransferase.

Authors:  R M Khomutov; H B Dixon; L V Vdovina; M P Kirpichnikov; Y V Morozov; E S Severin; E N Khurs
Journal:  Biochem J       Date:  1971-08       Impact factor: 3.857
  8 in total
  1 in total

1.  Inhibition of pig kidney dopa decarboxylase by coenzyme-5-hydroxytryptophan adducts.

Authors:  P Dominici; M Curini; A Minelli; C Borri Voltattorni
Journal:  Experientia       Date:  1984-08-15
  1 in total

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