Literature DB >> 8363725

Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?

T G Wegmann1, H Lin, L Guilbert, T R Mosmann.   

Abstract

Pregnant females are susceptible to intracellular pathogens and are biased towards humoral rather than cell-mediated immunity. Since TH1 cytokines compromise pregnancy and TH2 cytokines are produced at the maternal-fetal interface, we hypothesize that these TH2 cytokines inhibit TH1 responses, improving fetal survival but impairing responses against some pathogens.

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Year:  1993        PMID： 8363725     DOI： 10.1016/0167-5699(93)90235-D

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  496 in total

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