Literature DB >> 8363387

Ethambutol inhibition of glucose metabolism in mycobacteria: a possible target of the drug.

G Silve1, P Valero-Guillen, A Quemard, M A Dupont, M Daffe, G Laneelle.   

Abstract

The addition of D-arabinose, D-galactose, D-glucosamine, or D-mannose to the growth medium of Mycobacterium smegmatis suppressed the inhibitory effects of ethambutol both on acetate labeling of cell wall-linked mycolic acids and on the increase in the delipidated cell dry weight. The addition of D-glucose or D-fructose had no effect. It is proposed that ethambutol inhibits an early step of glucose conversion into the monosaccharides used for the biosynthesis of structurally and biologically important cell wall polysaccharides: arabinogalactan, arabinomannan, and peptidoglycan.

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Year:  1993        PMID： 8363387      PMCID： PMC188008          DOI： 10.1128/AAC.37.7.1536

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  Inhibition of synthesis of arabinogalactan by ethambutol in Mycobacterium smegmatis.

Authors:  K Takayama; J O Kilburn
Journal:  Antimicrob Agents Chemother       Date:  1989-09       Impact factor: 5.191

2.  Structure and antigenicity of the phosphorylated lipopolysaccharide antigens from the leprosy and tubercle bacilli.

Authors:  S W Hunter; H Gaylord; P J Brennan
Journal:  J Biol Chem       Date:  1986-09-15       Impact factor: 5.157

3.  Synergistic effects of antimycobacterial drug combinations on Mycobacterium avium complex determined radiometrically in liquid medium.

Authors:  S E Hoffner; S B Svenson; G Källenius
Journal:  Eur J Clin Microbiol       Date:  1987-10       Impact factor: 3.267

4.  Ethambutol in the initial treatment of pulmonary tuberculosis. U.S. Public Health Service tuberculosis therapy trials.

Authors:  B Doster; F J Murray; R Newman; S F Woolpert
Journal:  Am Rev Respir Dis       Date:  1973-02

5.  Effects of ethambutol on phospholipid metabolism in Mycobacterium smegmatis.

Authors:  J O Kilburn; K Takayama; E L Armstrong; J Greenberg
Journal:  Antimicrob Agents Chemother       Date:  1981-02       Impact factor: 5.191

6.  Ethambutol MICs and MBCs for Mycobacterium avium complex and Mycobacterium tuberculosis.

Authors:  L B Heifets; M D Iseman; P J Lindholm-Levy
Journal:  Antimicrob Agents Chemother       Date:  1986-12       Impact factor: 5.191

7.  Inhibition by ethambutol of mycolic acid transfer into the cell wall of Mycobacterium smegmatis.

Authors:  K Takayama; E L Armstrong; K A Kunugi; J O Kilburn
Journal:  Antimicrob Agents Chemother       Date:  1979-08       Impact factor: 5.191

8.  [Specific lipids from Mycobacterium ulcerans].

Authors:  M Daffé; M A Lanéelle; J Roussel; C Asselineau
Journal:  Ann Microbiol (Paris)       Date:  1984 Mar-Apr

9.  Isoniazid inhibition of mycolic acid synthesis by cell extracts of sensitive and resistant strains of Mycobacterium aurum.

Authors:  A Quémard; C Lacave; G Lanéelle
Journal:  Antimicrob Agents Chemother       Date:  1991-06       Impact factor: 5.191

10.  Mycolic acid synthesis by Mycobacterium aurum cell-free extracts.

Authors:  C Lacave; M A Lanéelle; G Lanéelle
Journal:  Biochim Biophys Acta       Date:  1990-02-23
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  9 in total

1.  Ethambutol resistance in Mycobacterium tuberculosis: critical role of embB mutations.

Authors:  S Sreevatsan; K E Stockbauer; X Pan; B N Kreiswirth; S L Moghazeh; W R Jacobs; A Telenti; J M Musser
Journal:  Antimicrob Agents Chemother       Date:  1997-08       Impact factor: 5.191

2.  Molecular genetic analysis of nucleotide polymorphisms associated with ethambutol resistance in human isolates of Mycobacterium tuberculosis.

Authors:  S V Ramaswamy; A G Amin; S Göksel; C E Stager; S J Dou; H El Sahly; S L Moghazeh; B N Kreiswirth; J M Musser
Journal:  Antimicrob Agents Chemother       Date:  2000-02       Impact factor: 5.191

3.  Mycobacterium tuberculosis embB codon 306 mutations confer moderately increased resistance to ethambutol in vitro and in vivo.

Authors:  Claudia Plinke; Kerstin Walter; Sahar Aly; Stefan Ehlers; Stefan Niemann
Journal:  Antimicrob Agents Chemother       Date:  2011-03-28       Impact factor: 5.191

Review 4.  Antimicrobial agent resistance in mycobacteria: molecular genetic insights.

Authors:  J M Musser
Journal:  Clin Microbiol Rev       Date:  1995-10       Impact factor: 26.132

5.  A single point mutation in the embB gene is responsible for resistance to ethambutol in Mycobacterium smegmatis.

Authors:  M A Lety; S Nair; P Berche; V Escuyer
Journal:  Antimicrob Agents Chemother       Date:  1997-12       Impact factor: 5.191

6.  Biogenesis of the mycobacterial cell wall and the site of action of ethambutol.

Authors:  K Mikusová; R A Slayden; G S Besra; P J Brennan
Journal:  Antimicrob Agents Chemother       Date:  1995-11       Impact factor: 5.191

7.  Antimycobacterial activities of antisense oligodeoxynucleotide phosphorothioates in drug-resistant strains.

Authors:  E Rapaport; A Levina; V Metelev; P C Zamecnik
Journal:  Proc Natl Acad Sci U S A       Date:  1996-01-23       Impact factor: 11.205

8.  Recognition of multiple effects of ethambutol on metabolism of mycobacterial cell envelope.

Authors:  L Deng; K Mikusová; K G Robuck; M Scherman; P J Brennan; M R McNeil
Journal:  Antimicrob Agents Chemother       Date:  1995-03       Impact factor: 5.191

9.  Susceptibilities of nontuberculosis mycobacterial species to amoxicillin-clavulanic acid alone and in combination with antimycobacterial agents.

Authors:  L J Utrup; T D Moore; P Actor; J A Poupard
Journal:  Antimicrob Agents Chemother       Date:  1995-07       Impact factor: 5.191
  9 in total

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