Literature DB >> 8361658

Voltage-dependent K+ currents in guinea pig Müller (glia) cells show different sensitivities to blockade by Ba2+.

W Reichelt1, T Pannicke.   

Abstract

The effect of externally applied Ba2+ and Na+ on K+ currents was investigated by means of whole-cell patch-clamp in isolated and in situ Müller cells from guinea pig retina. Müller cells express a typical set of K+ currents, i.e. an ohmic current, an inactivating inward current (IK(IR)), a delayed rectifier (IK(DR)) and an inactivating outward current (IK(A)). Inactivation of the inward current did not occur when extracellular Na+ was replaced by choline. When administered in increasing concentrations, Ba2+ blocked these K+ currents in a typical sequence: the ohmic current and IK(A) were most sensitive, followed by IK(IR), whereas IK(DR) was not completely blocked even in 1 mM Ba2+. The differential sensitivity of Müller cell K+ currents to external Ba2+ may be a tool which can be used to improve our understanding of the Müller cell response to physiological stimulation of the retina.

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Year:  1993        PMID： 8361658     DOI： 10.1016/0304-3940(93)90663-6

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  13 in total

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