Literature DB >> 8360103

Eupenifeldin, a novel cytotoxic bistropolone from Eupenicillium brefeldianum.

F Mayerl1, Q Gao, S Huang, S E Klohr, J A Matson, D R Gustavson, D M Pirnik, R L Berry, C Fairchild, W C Rose.   

Abstract

Eupenifeldin was isolated from cultures of Eupenicillium brefeldianum ATCC 74184 by extraction and crystallization. The compound was identified as a pentacyclic bistropolone on the basis of spectral data and its complete structure was established by single-crystal X-ray analysis. The compound is cytotoxic against the HCT-116 cell line and has in vivo antitumor activity in the P388 leukemia model.

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Year:  1993        PMID： 8360103     DOI： 10.7164/antibiotics.46.1082

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  8 in total

1.  Enzymatic Intermolecular Hetero-Diels-Alder Reaction in the Biosynthesis of Tropolonic Sesquiterpenes.

Authors:  Qibin Chen; Jie Gao; Cooper Jamieson; Jiawang Liu; Masao Ohashi; Jian Bai; Daojian Yan; Bingyu Liu; Yongsheng Che; Yanan Wang; K N Houk; Youcai Hu
Journal:  J Am Chem Soc       Date:  2019-09-03       Impact factor: 15.419

2.  Production of brefeldin-A.

Authors:  T G McCloud; M P Burns; F D Majadly; G M Muschik; D A Miller; K K Poole; J M Roach; J T Ross; W B Lebherz
Journal:  J Ind Microbiol       Date:  1995-07

Review 3.  Natural products from thioester reductase containing biosynthetic pathways.

Authors:  Michael W Mullowney; Ryan A McClure; Matthew T Robey; Neil L Kelleher; Regan J Thomson
Journal:  Nat Prod Rep       Date:  2018-09-19       Impact factor: 13.423

4.  Classification of Aspergillus, Penicillium, Talaromyces and related genera (Eurotiales): An overview of families, genera, subgenera, sections, series and species.

Authors:  J Houbraken; S Kocsubé; C M Visagie; N Yilmaz; X-C Wang; M Meijer; B Kraak; V Hubka; K Bensch; R A Samson; J C Frisvad
Journal:  Stud Mycol       Date:  2020-06-27       Impact factor: 16.097

5.  Delivery of eupenifeldin via polymer-coated surgical buttresses prevents local lung cancer recurrence.

Authors:  Zeinab Y Al Subeh; Ngoc-Quynh Chu; Jeremy T Korunes-Miller; Lillian L Tsai; Tyler N Graf; Yin P Hung; Cedric J Pearce; Mark W Grinstaff; Aaron H Colby; Yolonda L Colson; Nicholas H Oberlies
Journal:  J Control Release       Date:  2021-01-21       Impact factor: 9.776

6.  Total Synthesis and Computational Investigations of Sesquiterpene-Tropolones Ameliorate Stereochemical Inconsistencies and Resolve an Ambiguous Biosynthetic Relationship.

Authors:  Christopher Y Bemis; Chad N Ungarean; Alexander S Shved; Cooper S Jamieson; Taehwan Hwang; Ken S Lee; K N Houk; David Sarlah
Journal:  J Am Chem Soc       Date:  2021-04-07       Impact factor: 16.383

7.  Aspergillus hancockii sp. nov., a biosynthetically talented fungus endemic to southeastern Australian soils.

Authors:  John I Pitt; Lene Lange; Alastair E Lacey; Daniel Vuong; David J Midgley; Paul Greenfield; Mark I Bradbury; Ernest Lacey; Peter K Busk; Bo Pilgaard; Yit-Heng Chooi; Andrew M Piggott
Journal:  PLoS One       Date:  2017-04-05       Impact factor: 3.240

Review 8.  Stereochemical and Biosynthetic Rationalisation of the Tropolone Sesquiterpenoids.

Authors:  Lei Li; Russell J Cox
Journal:  J Fungi (Basel)       Date:  2022-08-31
  8 in total

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