Literature DB >> 8357611

An immunohistochemical and electrophysiological study on Isk protein in the stria vascularis of the guinea pig.

N Mori1, M Sakagami, K Fukazawa, T Matsunaga.   

Abstract

The reaction product against rat Isk protein antibody was demonstrated on the endolymphatic surface of the marginal cell of the guinea pig, using an immunohistochemical method. Clofilium, a potassium channel blocker which has been previously found to block rat kidney Isk channels, decreased the endocochlear potential (EP) when applied by perilymphatic perfusion and iontophoresis into endolymph. This finding of a decreased EP supports the presence of Isk protein on the endolymphatic surface of the marginal cell.

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Year:  1993        PMID： 8357611     DOI： 10.1007/bf00171709

Source DB:  PubMed          Journal:  Eur Arch Otorhinolaryngol        ISSN： 0937-4477            Impact factor:   2.503


  14 in total

1.  Cellular localization of rat Isk protein in the stria vascularis by immunohistochemical observation.

Authors:  M Sakagami; K Fukazawa; T Matsunaga; H Fujita; N Mori; T Takumi; H Ohkubo; S Nakanishi
Journal:  Hear Res       Date:  1991-11       Impact factor: 3.208

2.  Electrophysiological measurements of the stria vascularis potentials in vivo.

Authors:  I Melichar; J Syka
Journal:  Hear Res       Date:  1987       Impact factor: 3.208

3.  Cloning and expression of the delayed-rectifier IsK channel from neonatal rat heart and diethylstilbestrol-primed rat uterus.

Authors:  K Folander; J S Smith; J Antanavage; C Bennett; R B Stein; R Swanson
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

4.  Positive endocochlear potential: mechanism of production by marginal cells of stria vascularis.

Authors:  F F Offner; P Dallos; M A Cheatham
Journal:  Hear Res       Date:  1987       Impact factor: 3.208

5.  Mechanisms of endocochlear potential generation by stria vascularis.

Authors:  A N Salt; I Melichar; R Thalmann
Journal:  Laryngoscope       Date:  1987-08       Impact factor: 3.325

6.  Cloning of a membrane protein that induces a slow voltage-gated potassium current.

Authors:  T Takumi; H Ohkubo; S Nakanishi
Journal:  Science       Date:  1988-11-18       Impact factor: 47.728

7.  Ion transport in guinea pig cochlea. I. Potassium and sodium transport.

Authors:  T Konishi; P E Hamrick; P J Walsh
Journal:  Acta Otolaryngol       Date:  1978 Jul-Aug       Impact factor: 1.494

8.  Selective inhibition of potassium currents in rat ventricle by clofilium and its tertiary homolog.

Authors:  N A Castle
Journal:  J Pharmacol Exp Ther       Date:  1991-04       Impact factor: 4.030

9.  Characterization of potassium permeability of cochlear duct by perilymphatic perfusion of barium.

Authors:  D C Marcus
Journal:  Am J Physiol       Date:  1984-09

10.  Functional importance of sodium and potassium in the guinea pig cochlea studied with amiloride and tetraethylammonium.

Authors:  A N Salt; T Konishi
Journal:  Jpn J Physiol       Date:  1982
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  2 in total

1.  I(sK) Channel in Strial Marginal Cells. Voltage-Dependence, Ion-Selectivity, Inhibition by 293B and Sensitivity to Clofilium.

Authors:  Zhijun Shen; Daniel C Marcus; Hiroshi Sunose; Toshihiko Chiba; Philine Wangemann
Journal:  Audit Neurosci       Date:  1997

2.  Potassium currents in isolated deiters' cells of Guinea pig.

Authors:  Jong Woo Chung; Eui Chol Nam; Won Tae Kim; Jae Boum Youm; Chae Hun Leem
Journal:  Korean J Physiol Pharmacol       Date:  2013-12-16       Impact factor: 2.016
  2 in total

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