| Literature DB >> 8355657 |
J Daniel1.
Abstract
The recognition that cellular regulatory circuitry is composed of antagonistic elements has made possible a new approach to the selection of regulatory genes, called the gene-gene interference method. The method was used to identify and isolate genes possibly related in an antagonistic way to protein kinase A. Two such genes were recovered: ART1 encodes a potential regulator of cytokinesis and KAI1 appears to be involved in the Start control. The principles of the gene-gene interference method are discussed, as well as its possible general use for 'walking' within the cellular regulatory networks of eukaryotes.Entities:
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Year: 1993 PMID: 8355657 DOI: 10.1007/bf00277063
Source DB: PubMed Journal: Mol Gen Genet ISSN: 0026-8925