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Literature DB >> 3553962

Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2.

Abstract

A human homologue of the cdc2 gene has been cloned by expressing a human cDNA library in fission yeast and selecting for clones that can complement a mutant of cdc2. The predicted protein sequence of the human homologue is very similar to that of the yeast cdc2 gene. These data indicate that elements of the mechanism by which the cell cycle is controlled are likely to be conserved between yeast and humans.

Entities: Gene Species

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Year: 1987 PMID： 3553962 DOI： 10.1038/327031a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

330 in total

1. P-Selectin: Basic Aspects.

Authors:
Journal: J Thromb Thrombolysis Date: 1998-09 Impact factor: 2.300

2. Cell cycle-independent removal of UV-induced pyrimidine dimers from the promoter and the transcription initiation domain of the human CDC2 gene.

Authors: S Tommasi; A B Oxyzoglou; G P Pfeifer
Journal: Nucleic Acids Res Date: 2000-10-15 Impact factor: 16.971

9. Mammalian growth-associated H1 histone kinase: a homolog of cdc2+/CDC28 protein kinases controlling mitotic entry in yeast and frog cells.

Authors: T A Langan; J Gautier; M Lohka; R Hollingsworth; S Moreno; P Nurse; J Maller; R A Sclafani
Journal: Mol Cell Biol Date: 1989-09 Impact factor: 4.272

10. Cauliflower mosaic virus promoters direct efficient expression of a bacterial G418 resistance gene in Schizosaccharomyces pombe.

Authors: H Gmünder; J Kohli
Journal: Mol Gen Genet Date: 1989-12

Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2.

1. P-Selectin: Basic Aspects.

2. Cell cycle-independent removal of UV-induced pyrimidine dimers from the promoter and the transcription initiation domain of the human CDC2 gene.

3. Centenary Nobel Prize in Physiology or Medicine for the cell cycle.

4. Vertebrate and yeast calmodulin, despite significant sequence divergence, are functionally interchangeable.

5. pp39mos is associated with p34cdc2 kinase in c-mosxe-transformed NIH 3T3 cells.

Review 6. Natural genetic engineering in evolution.

7. Genetic dissection of the signaling domain of a mammalian steroid receptor in yeast.

Review 8. Cell cycle, CDKs and cancer: a changing paradigm.

9. Mammalian growth-associated H1 histone kinase: a homolog of cdc2+/CDC28 protein kinases controlling mitotic entry in yeast and frog cells.

10. Cauliflower mosaic virus promoters direct efficient expression of a bacterial G418 resistance gene in Schizosaccharomyces pombe.