Literature DB >> 8348929

Protective efficacy of BCG vaccine against leprosy in southern Malaŵi.

D M Baker1, J S Nguyen-Van-Tam, S J Smith.   

Abstract

This paper describes a matched case-control study to determine the efficacy of BCG vaccine in preventing the occurrence of leprosy in southern Malaŵi, a previously unstudied area. The BCG immunization rate amongst 145 individuals with leprosy was 44.8%, compared to 62.5% in 290 matched controls. The protective efficacy of BCG vaccine against leprosy in this region was estimated to be 63.6%; smallpox immunization had no effect. These findings support the view that BCG vaccine should be considered as a control measure in areas where leprosy is endemic.

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Year:  1993        PMID： 8348929      PMCID： PMC2271193          DOI： 10.1017/s0950268800056636

Source DB:  PubMed          Journal:  Epidemiol Infect        ISSN： 0950-2688            Impact factor:   2.451


  16 in total

1.  The occurrence of pulmonary lesions in BCG-vaccinated and unvaccinated persons.

Authors:  S C STEIN; J D ARONSON
Journal:  Am Rev Tuberc       Date:  1953-11

Review 2.  Modern vaccines. Mycobacterial diseases.

Authors:  P E Fine; L C Rodrigues
Journal:  Lancet       Date:  1990-04-28       Impact factor: 79.321

3.  Untreated leprosy: probability for shifts in Ridley-Jopling classification. Development of "flares", or disappearance of clinically apparent disease.

Authors:  G C Scott; D A Russell; C R Boughton; D R Vincin
Journal:  Int J Lepr Other Mycobact Dis       Date:  1976 Jan-Jun

4.  BCG vaccination of children against leprosy: nine-year findings of the controlled WHO trial in Burma.

Authors:  L M Bechelli; K Lwin; P Gallego Garbajosa; K Uemura; T Sundaresan; C Tamondong; M Matejka; H Sansarricq; J Walter
Journal:  Bull World Health Organ       Date:  1974       Impact factor: 9.408

5.  [Observation concerning the protective effect of BCG vaccination in the rural population of South India: report number 4].

Authors:  J Frimodt-Möller; G S Acharyulu; K K Pillai
Journal:  Bull Int Union Tuberc       Date:  1973-06

6.  Tuberculosis studies in Muscogee County, Georgia. VII. A twenty-year evaluation of BCG vaccination in a school population.

Authors:  G W Comstock; R G Webster
Journal:  Am Rev Respir Dis       Date:  1969-12

7.  Protective efficacy of BCG against leprosy in Northern Malawi.

Authors:  P E Fine; J M Ponnighaus; N Maine; J A Clarkson; L Bliss
Journal:  Lancet       Date:  1986-08-30       Impact factor: 79.321

8.  Assessment of the protective efficacy of vaccines against common diseases using case-control and cohort studies.

Authors:  P G Smith; L C Rodrigues; P E Fine
Journal:  Int J Epidemiol       Date:  1984-03       Impact factor: 7.196

9.  Retrospective assessment of the effectiveness of BCG vaccination against tuberculosis using the case-control method.

Authors:  P G Smith
Journal:  Tubercle       Date:  1982-03

10.  BCG vaccination of children against leprosy in Uganda: final results.

Authors:  S J Stanley; C Howland; M M Stone; I Sutherland
Journal:  J Hyg (Lond)       Date:  1981-10
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  2 in total

1.  Recombinant Mycobacterium smegmatis with a pMyong2 vector expressing Human Immunodeficiency Virus Type I Gag can induce enhanced virus-specific immune responses.

Authors:  Byoung-Jun Kim; Jeong-Ryeol Gong; Ga-Na Kim; Bo-Ram Kim; So-Young Lee; Yoon-Hoh Kook; Bum-Joon Kim
Journal:  Sci Rep       Date:  2017-03-16       Impact factor: 4.379

2.  Bacillus of Calmette and Guérin (BCG) and the risk of leprosy in Ciudad del Este, Paraguay, 2016-2017.

Authors:  Nancy Carolina Cuevas; Victor M Cardenas
Journal:  Epidemiol Health       Date:  2021-09-08
  2 in total

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