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Literature DB >> 8340108

Age-related nonrandom chromosomal abnormalities in human low-grade astrocytomas.

G Thiel¹, T Lozanova, S Vogel, D Kintzel, W Jänisch, R Witkowski.

Abstract

We report a cytogenetic investigation of 55 low-grade astrocytomas in 52 patients, 15 children and 37 adults. In addition to numerical aberrations such as trisomy 7 and gonosomal losses, we found structural and/or numerical aberrations of chromosome 1 in eight astrocytomas. There was a striking difference between the rearranged chromosomes in pediatric and adult patients. Whereas the pediatric tumors revealed monosomies 1p with accompanying trisomy 1q, the astrocytomas in adults showed partial or complete monosomies 1q.

Entities: Disease Species

Mesh：

Year: 1993 PMID： 8340108 DOI： 10.1007/bf00205078

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

13 in total

1. Chromosomal patterns in human malignant astrocytomas.

Authors: J A Rey; M J Bello; J M de Campos; M E Kusak; C Ramos; J Benitez
Journal: Cancer Genet Cytogenet Date: 1987-12

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Journal: J Natl Cancer Inst Date: 1985-07 Impact factor: 13.506

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Journal: Cancer Genet Cytogenet Date: 1990-07-01

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Authors: S H Bigner; J Mark; P C Burger; M S Mahaley; D E Bullard; L H Muhlbaier; D D Bigner
Journal: Cancer Res Date: 1988-01-15 Impact factor: 12.701

5. Trisomy 15 in chorionic villi and Prader-Willi syndrome at birth.

Authors: N Morichon-Delvallez; P Mussat; Y Dumez; M Vekemans
Journal: Prenat Diagn Date: 1993-04 Impact factor: 3.050

6. Karyotypes in 90 human gliomas.

Authors: G Thiel; T Losanowa; D Kintzel; G Nisch; H Martin; K Vorpahl; R Witkowski
Journal: Cancer Genet Cytogenet Date: 1992-02

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Authors: N B Atkin; M C Baker
Journal: Cancer Genet Cytogenet Date: 1985-02-15

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Authors: R B Jenkins; D W Kimmel; C A Moertel; C G Schultz; B W Scheithauer; P J Kelly; G W Dewald
Journal: Cancer Genet Cytogenet Date: 1989-06

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Authors: J A Rey; M J Bello; J M de Campos; M E Kusak; S Moreno
Journal: Cancer Genet Cytogenet Date: 1987-12

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Authors: V Brito-Babapulle; N B Atkin
Journal: Cancer Genet Cytogenet Date: 1981-11

5 in total

1. Comparative genomic hybridization of human malignant gliomas reveals multiple amplification sites and nonrandom chromosomal gains and losses.

Authors: E Schröck; G Thiel; T Lozanova; S du Manoir; M C Meffert; A Jauch; M R Speicher; P Nürnberg; S Vogel; W Jänisch
Journal: Am J Pathol Date: 1994-06 Impact factor: 4.307