Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Chromosomal patterns in human malignant astrocytomas.

Literature DB >> 2824025

Chromosomal patterns in human malignant astrocytomas.

J A Rey¹, M J Bello, J M de Campos, M E Kusak, C Ramos, J Benitez.

Abstract

Cytogenetic analysis by direct and/or in vitro preparations was performed on 34 malignant astrocytomas. Thirty tumors showed near-diploid chromosome numbers, whereas, tritetraploid chromosome complements were present in four tumors. The most frequent chromosomal changes implied numerical deviations by a gain of chromosomes #7, #19, and #20, and by losses of #10, #22, and Y. Structural rearrangements were present in stem- or side lines of 24 tumors. Although no common chromosomal rearrangement seems to exist among those tumors, chromosomes #1, #6, #7, and #9 were predominantly involved. Polysomy and structural rearrangements of chromosome #7 could be related to the overexpression of epidermal growth factor gene, previously observed in some malignant gliomas.

Entities: Disease Species

Mesh：

Year: 1987 PMID： 2824025 DOI： 10.1016/0165-4608(87)90232-9

Source DB: PubMed Journal: Cancer Genet Cytogenet ISSN： 0165-4608

Keyword Cloud
Cited

15 in total

1. Loss of distinct regions on the short arm of chromosome 17 associated with tumorigenesis of human astrocytomas.

Authors: M el-Azouzi; R Y Chung; G E Farmer; R L Martuza; P M Black; G A Rouleau; C Hettlich; E T Hedley-Whyte; N T Zervas; K Panagopoulos
Journal: Proc Natl Acad Sci U S A Date: 1989-09 Impact factor: 11.205

2. Comparative genomic hybridization of human malignant gliomas reveals multiple amplification sites and nonrandom chromosomal gains and losses.

Authors: E Schröck; G Thiel; T Lozanova; S du Manoir; M C Meffert; A Jauch; M R Speicher; P Nürnberg; S Vogel; W Jänisch
Journal: Am J Pathol Date: 1994-06 Impact factor: 4.307

3. Mitotic recombination of chromosome 17 in astrocytomas.

Authors: C D James; E Carlbom; M Nordenskjold; V P Collins; W K Cavenee
Journal: Proc Natl Acad Sci U S A Date: 1989-04 Impact factor: 11.205

Review 4. Genetic alterations in glioma and medulloblastoma.

Authors: B K Rasheed; S H Bigner
Journal: Cancer Metastasis Rev Date: 1991-12 Impact factor: 9.264

5. BCNU-sensitivity in parental cells and clones from four freshly resected near-diploid human gliomas: an astrocytoma, an anaplastic astrocytoma and two glioblastomas multiforme.

Authors: J R Shapiro; S A Ebrahim; A N Mohamed; P Y Pu; W R Shapiro
Journal: J Neurooncol Date: 1993-03 Impact factor: 4.130

Chromosomal patterns in human malignant astrocytomas.

1. Loss of distinct regions on the short arm of chromosome 17 associated with tumorigenesis of human astrocytomas.

2. Comparative genomic hybridization of human malignant gliomas reveals multiple amplification sites and nonrandom chromosomal gains and losses.

3. Mitotic recombination of chromosome 17 in astrocytomas.

Review 4. Genetic alterations in glioma and medulloblastoma.

5. BCNU-sensitivity in parental cells and clones from four freshly resected near-diploid human gliomas: an astrocytoma, an anaplastic astrocytoma and two glioblastomas multiforme.

6. Karyotype analyses of 20 human glioma cell lines.

Review 7. Genetics of primary brain tumors: a review.

8. Age-related nonrandom chromosomal abnormalities in human low-grade astrocytomas.

Review 9. Temporal trends among childhood brain tumor biopsies. The Childhood Brain Tumor Consortium.

10. A clonal translocation t(10;21) in an optic glioma of a patient with neurofibromatosis type 1 (NF 1).