Literature DB >> 8339778

Microvascular density of the human paraventricular nucleus decreases with aging but not hypertension.

W B Abernethy1, M A Bell, M Morris, D M Moody.   

Abstract

Microvascular density was determined in the supraoptic nuclei (SON) and paraventricular nuclei (PVN) of fixed brain tissue from 19 human subjects ranging in age from 30 to 85 years. Eight of these patients had hypertension. No sex- or hypertension-related differences in microvascular density were found in either the SON or PVN. However, capillary density decreased in the PVN with aging. These results indicate a differential pattern of microvascular loss in the human hypothalamus with aging.

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Year:  1993        PMID： 8339778     DOI： 10.1006/exnr.1993.1095

Source DB:  PubMed          Journal:  Exp Neurol        ISSN： 0014-4886            Impact factor:   5.330


  22 in total

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Journal:  Hum Brain Mapp       Date:  2017-04-17       Impact factor: 5.038

Review 7.  Review: cerebral microvascular pathology in ageing and neurodegeneration.

Authors:  W R Brown; C R Thore
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8.  Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging.

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Journal:  Age (Dordr)       Date:  2016-09-09

9.  Aging-associated changes in cerebral vasculature and blood flow as determined by quantitative optical coherence tomography angiography.

Authors:  Yuandong Li; Woo June Choi; Wei Wei; Shaozhen Song; Qinqin Zhang; Jialing Liu; Ruikang K Wang
Journal:  Neurobiol Aging       Date:  2018-06-22       Impact factor: 4.673

10.  The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss.

Authors:  Anna Secher; Jacob Jelsing; Arian F Baquero; Jacob Hecksher-Sørensen; Michael A Cowley; Louise S Dalbøge; Gitte Hansen; Kevin L Grove; Charles Pyke; Kirsten Raun; Lauge Schäffer; Mads Tang-Christensen; Saurabh Verma; Brent M Witgen; Niels Vrang; Lotte Bjerre Knudsen
Journal:  J Clin Invest       Date:  2014-09-09       Impact factor: 14.808
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