Literature DB >> 8331384

A protein tyrosine phosphatase expressed within dopaminoceptive neurons of the basal ganglia and related structures.

P J Lombroso1, J R Naegele, E Sharma, M Lerner.   

Abstract

Immunocytochemical and biochemical studies were conducted to characterize a brain-specific protein tyrosine phosphatase, designated STEP for striatal enriched phosphatase. STEP immunoreactivity was most intense in select regions of the CNS receiving a dopaminergic input, and was localized to cell bodies, dendrites, and axonal processes. Western blot analyses of rat brain homogenates revealed a triplet of polypeptides with relative mobilities (M(r)) of 46 kDa, 37 kDa, and 33 kDa enriched within the striatum. Phase separation of protein homogenates by Triton X-114 extraction indicated that this triplet was enriched in soluble but not membrane fractions. Affinity-purified STEP fusion protein exhibited phosphatase activity while a mutated form of the STEP fusion protein (Cys300Ser) showed no demonstrable phosphatase activity.

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Year:  1993        PMID： 8331384      PMCID： PMC6576687     

Source DB:  PubMed          Journal:  J Neurosci        ISSN： 0270-6474            Impact factor:   6.167


  65 in total

1.  Differential interaction of the tyrosine phosphatases PTP-SL, STEP and HePTP with the mitogen-activated protein kinases ERK1/2 and p38alpha is determined by a kinase specificity sequence and influenced by reducing agents.

Authors:  Juan José Muñoz; Céline Tárrega; Carmen Blanco-Aparicio; Rafael Pulido
Journal:  Biochem J       Date:  2003-05-15       Impact factor: 3.857

2.  Down-regulation of BDNF in cell and animal models increases striatal-enriched protein tyrosine phosphatase 61 (STEP61 ) levels.

Authors:  Jian Xu; Pradeep Kurup; Garikoitz Azkona; Tyler D Baguley; Ana Saavedra; Angus C Nairn; Jonathan A Ellman; Esther Pérez-Navarro; Paul J Lombroso
Journal:  J Neurochem       Date:  2015-09-17       Impact factor: 5.372

Review 3.  Taking STEPs forward to understand fragile X syndrome.

Authors:  Susan M Goebel-Goody; Paul J Lombroso
Journal:  Results Probl Cell Differ       Date:  2012

Review 4.  Synaptic plasticity: one STEP at a time.

Authors:  Steven P Braithwaite; Surojit Paul; Angus C Nairn; Paul J Lombroso
Journal:  Trends Neurosci       Date:  2006-06-30       Impact factor: 13.837

5.  The STEP61 interactome reveals subunit-specific AMPA receptor binding and synaptic regulation.

Authors:  Sehoon Won; Salvatore Incontro; Yan Li; Roger A Nicoll; Katherine W Roche
Journal:  Proc Natl Acad Sci U S A       Date:  2019-04-01       Impact factor: 11.205

Review 6.  Beta-amyloid modulation of synaptic transmission and plasticity.

Authors:  Deepa V Venkitaramani; Jeannie Chin; William J Netzer; Gunnar K Gouras; Sylvain Lesne; Roberto Malinow; Paul J Lombroso
Journal:  J Neurosci       Date:  2007-10-31       Impact factor: 6.167

7.  Expression of PTPH1, a rat protein tyrosine phosphatase, is restricted to the derivatives of a specific diencephalic segment.

Authors:  M Sahin; S A Slaugenhaupt; J F Gusella; S Hockfield
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-15       Impact factor: 11.205

8.  STEP61: a member of a family of brain-enriched PTPs is localized to the endoplasmic reticulum.

Authors:  A Bult; F Zhao; R Dirkx; E Sharma; E Lukacsi; M Solimena; J R Naegele; P J Lombroso
Journal:  J Neurosci       Date:  1996-12-15       Impact factor: 6.167

9.  Inhibition of striatal-enriched tyrosine phosphatase 61 in the dorsomedial striatum is sufficient to increased ethanol consumption.

Authors:  Emmanuel Darcq; Sami Ben Hamida; Su Wu; Khanky Phamluong; Viktor Kharazia; Jian Xu; Paul Lombroso; Dorit Ron
Journal:  J Neurochem       Date:  2014-03-27       Impact factor: 5.372

10.  Zn2+-dependent Activation of the Trk Signaling Pathway Induces Phosphorylation of the Brain-enriched Tyrosine Phosphatase STEP: MOLECULAR BASIS FOR ZN2+-INDUCED ERK MAPK ACTIVATION.

Authors:  Ranjana Poddar; Sathyanarayanan Rajagopal; C William Shuttleworth; Surojit Paul
Journal:  J Biol Chem       Date:  2015-11-16       Impact factor: 5.157
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