Literature DB >> 8325367

MFH-1, a new member of the fork head domain family, is expressed in developing mesenchyme.

N Miura1, A Wanaka, M Tohyama, K Tanaka.   

Abstract

We have isolated a novel mouse gene, MFH-1 (mesenchyme fork head 1) that is related to the Drosophila fork head and rat HNF3 genes. MFH-1 encodes a distinct fork head domain that is classified into a distinct subfamily. A recombinant MFH-1 protein could bind to the HNF3 binding site. MFH-1 is expressed temporally in developing embryos, first in the non-notochordal mesoderm and later in areas of mesenchymal condensation in the trunk, head, and limbs. Our results suggest that MFH-1 might be involved in the formation of special mesenchymal tissues.

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Year:  1993        PMID： 8325367     DOI： 10.1016/0014-5793(93)81785-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  23 in total

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