Literature DB >> 832531

Bactericidal synergistic effect due to chloramphenicol-induced inhibition of staphyloccal penicillinase.

J Michel, J Jacobs, T Sacks.   

Abstract

A synergistic bactericidal effect of chloramphenicol and penicillin-G was observed with 17 out of 20 beta-lactamase producing strains of Staphylococcus aureus. The synergism was due to chloramphenicol-induced inhibition of beta-lactamase production. With seven of the strains the synergistic effect was operative only with subinhibitory concentrations of chloramphenicol, while higher concentrations produced antagonism.

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Year:  1977        PMID： 832531     DOI： 10.1159/000221968

Source DB:  PubMed          Journal:  Chemotherapy        ISSN： 0009-3157            Impact factor:   2.544


  4 in total

1.  Mechanism of penicillin-erythromycin synergy on antibiotic-resistant Staphylococcus aureus.

Authors:  N E Allen; J K Epp
Journal:  Antimicrob Agents Chemother       Date:  1978-05       Impact factor: 5.191

2.  Bactericidal effect of combinations of antimicrobial drugs and antineoplastic antibiotics against gram-negative bacilli.

Authors:  J Michel; J Y Jacobs; T Sacks
Journal:  Antimicrob Agents Chemother       Date:  1979-12       Impact factor: 5.191

3.  Effects of subminimal inhibitory concentrations of chloramphenicol, erythromycin and penicillin on group A streptococci.

Authors:  J Michel; M Ferne; R Borinski; Z Kornberg; S Bergner-Rabinowitz; I Ginsburg
Journal:  Eur J Clin Microbiol       Date:  1982-12       Impact factor: 3.267

4.  Effects of subminimal inhibitory concentrations of Erythromycin, Clindamycin, and Pristinamycin on the penicillinase production of Staphlyococcus aureus.

Authors:  J Michel; P Stessman; J Stessman
Journal:  Antimicrob Agents Chemother       Date:  1980-01       Impact factor: 5.191
  4 in total

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